Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS) - Correlation with simultaneous rCBF-PET measurements
Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS) - Correlation with simultaneous rCBF-PET measurements
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DOI：
10.1016/s0006-8993(97)00122-4
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发表时间：
1997-05-02
期刊：
影响因子：
2.9
通讯作者：
Villringer, A
中科院分区：
文献类型：
--
作者：
Hock, C;Villringer, K;Villringer, A
我们使用近红外光谱 (NIRS) 无创性地研究阿尔茨海默病 (AD) 患者在执行语言流利性任务期间额叶和顶叶皮层脑血红蛋白氧合的变化。健康老年受试者 n = 19，年龄 67 +/- 10 岁）显示出左上顶叶皮质的氧合血红蛋白 [HbO(2)]（平均值（任意单位）+/- S.E.M.，1.44 +/- 0.59）和总血红蛋白 [HbT] (0.92 +/- 0.81) 浓度高于左上顶叶皮质，而 AD 患者（n = 19，年龄71 +/- 10 年）显示 [HbO(2)]（-3.26 +/- 1.30，P < 0.01）和 [HbT]（-4.45 +/- 1.57，P < 0.01）显着下降。两组的 [HbR] 均略有下降（分别为 -0.62 +/- 0.29 和 -1.18 +/- 0.40）。使用放置在左上部分皮质和左前额叶皮质上的两对 MRS 光极，在执行任务期间证明健康老年受试者（n = 8，年龄 60 +/- 15）两个皮质区域的 [HbO(2)] 和 [HbT] 同时增加，AD 患者（n = 10，年龄 65 +/- 13 岁）显示 [HbO(2)] 和 [HbO(2)] 和 [HbT] 降低。顶叶皮质中的 [HbT] 增加，同时额叶皮质中的 [HbO(2)] 和 [HbT] 增加。同时 NIRS-[HbT] 和 PET-rCBF 测量显示出显着的相关性，无论是在使用皮质阈值近似的“香蕉”形体积中计算，还是在头部表面光极下方的脑组织半球形体积中计算（AD 患者，n = 10）。该相关性取决于近红外光的假设穿透深度，并且当使用 0.45 cm 至 1.35 cm 的半球半径计算时，对于所有三个 NIRS 变量（[HbO(2)]、[HbR] 和 [HbT]）而言，相关性最佳。总之，在阿尔茨海默病中，大脑功能激活期间可能会出现局部脑血流量和脑血红蛋白氧合的显着减少，可能主要发生在退化的大脑区域，例如顶叶皮层。 (C) 爱思唯尔科学有限公司
We used near-infrared spectroscopy (NIRS) to study non-invasively changes in cerebral hemoglobin oxygenation in the frontal and parietal cortex during performance of a verbal fluency task in patients with Alzheimer's disease (AD). Whereas healthy elderly subjects n = 19, age 67 +/- 10 years) showed increases in concentrations of oxygenated hemoglobin [HbO(2)] (mean (arbitrary units) +/- S.E.M., 1.44 +/- 0.59) and total hemoglobin [HbT] (0.92 +/- 0.81) over the left superior parietal cortex, patients with AD (n = 19, age 71 +/- 10 years) showed significant decreases in [HbO(2)] (-3.26 +/- 1.30, P < 0.01) as well as [HbT] (-4.45 +/- 1.57, P < 0.01). [HbR] decreased slightly in both groups (-0.62 +/- 0.29 and -1.18 +/- 0.40, respectively). Using two pairs of MRS optodes placed on the left superior partietal cortex and on the left prefrontal cortex simultaneous increases in [HbO(2)] as well as [HbT] in both cortical regions in the healthy elderly subjects (n = 8, age 60 +/- 15) were demonstrated during performance of the task, AD patients (n = 10, age 65 +/- 13 years) showed decreases in [HbO(2)] and [HbT] in the parietal cortex and, at the same time, increases in [HbO(2)] and [HbT] in the frontal cortex. Simultaneous NIRS-[HbT] and PET-rCBF measurements showed a significant correlation both when calculated in a 'banana' shaped volume approximated by using cortical thresholds as well as when calculated in a semisphere volume of brain tissue beneath the optodes placed on the head surface (patients with AD, n = 10). The correlation was dependent on the assumed penetration depth of the near-infrared light and was best for all three NIRS variables ([HbO(2)], [HbR] and [HbT]) when calculated using a semisphere radius of 0.45 cm to 1.35 cm. In conclusion, in Alzheimer's disease a marked reduction of regional cerebral blood flow and cerebral hemoglobin oxygenation may occur during activation of brain function, probably mainly in degenerating brain areas, such as the parietal cortex. (C) Elsevier Science B.V.