Treatment of infant colic with amino acid-based infant formula: a preliminary study.
Treatment of infant colic with amino acid-based infant formula: a preliminary study.
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用氨基酸婴儿配方奶粉治疗婴儿绞痛：初步研究。
DOI：
10.1080/080352500750029004
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
KulczyckiJr,A
中科院分区：
文献类型：
--
作者：
Estep,DC;KulczyckiJr,A
婴儿绞痛是婴儿期的一种常见疾病，其特征是过度哭泣和大惊小怪。在这项初步研究中，我们检查了Neocate（一种基于氨基酸的配方奶粉）是否会被3 - 7周龄的配方奶粉喂养的绞痛婴儿接受，以及Neocate是否会改善他们的症状。使用巴尔式婴儿行为日记对6名绞痛婴儿进行了研究，研究对象为3 - 6天的当前配方奶粉，然后是5 - 17天的Neocate。所有婴儿均对Neocate耐受良好，并且通常在1-2天内全部改善。哭泣和大惊小怪的总时间平均减少了45%，每天减少1.0至5.2小时。在绞痛症状改善后，用75 mg浓度为1 mg/ml的牛IgG口服剂量激发婴儿，以评估其在绞痛中的潜在作用。牛IgG的挑战导致增加哭泣和大惊小怪的行为，这表明这种蛋白质可能是重要的病因。
Infant colic, a common disorder of infancy, is characterized by excessive crying and fussing. In this preliminary study we examined whether Neocate, an amino acid‐based formula, would be accepted by formula‐fed infants with colic, 3‐7 wk of age, and whether Neocate would improve their symptoms. Six infants with colic were studied using Barr‐type infant behavior diaries for 3‐6 d on their current formula and then for 5‐17 d on Neocate exclusively. All infants tolerated Neocate well and all improved, usually within 1–2 d. The total time spent crying and fussing was reduced by an average of 45%, representing a decrease of 1.0 to 5.2 h daily. After colic symptoms improved, infants were challenged with oral doses of 75 mg of bovine IgG at a 1 mg/ml concentration in order to assess its potential role in colic. Bovine IgG challenges resulted in increased crying and fussing behavior, suggesting that this protein may be etiologically important.