A theory of modular evolution for bacteriophages.
A theory of modular evolution for bacteriophages.
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DOI：
10.1111/j.1749-6632.1980.tb27987.x
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发表时间：
1980-01-01
影响因子：
5.2
通讯作者：
Botstein, D
中科院分区：
文献类型：
--
作者：
Botstein, D
病毒进化的模块理论在肠道细菌的温和噬菌体中有明确的实验支持。然而，在其他噬菌体家族中也有类似的遗传和DNA异源双链体证据表明这种进化：肠道的毒性噬菌体包括几个家族：T-even组，T3-T7组（在不同的细菌物种中有许多成员，包括像E.大肠杆菌和新月柄杆菌。它很好地解释了非常相似的同源噬菌体扩散到宿主体内的原因，而宿主的DNA在核苷酸序列上彼此差异很大。它还解释了当功能单位（包括蛋白质编码区）更快地分化时，调控机制的严格维持。还应该指出的是，使噬菌体的模块化进化看起来有利的考虑因素同样适用于高等生物的病毒。此外，在动物病毒中观察到的异源双链体相似性让人想起在噬菌体中发现的情况。在差异很大的宿主中发现的病毒，其相似性比预期的要大得多;动物病毒很可能也是作为一个可互换模块的群体进化而来的。
The modular theory of virus evolution has clear experimental support among the temperate bacteriophages of the enteric bacteria. However, there is also similar genetic and DNA heteroduplex evidence for such evolution among other families of bacteriophages: the virulent bacteriophages of the enterics comprise several families: the T-even group, the T3-T7 group (which has many members among different species of bacteria, including bacteria as widely divergent as E. coli and Caulobacter crescentus. It nicely explains the diffusion of very similar homologous bacteriophages into hosts whose own DNAs have diverged very greatly from each other in nucleotide sequence. It also accounts for the rigorous maintenance of regulatory schemes while units of function (including regions coding for proteins) diverge more rapidly. It should also be noted that the considerations that make modular evolution seem advantageous for bacteriophages apply equally well to viruses of higher organisms. Furthermore, the kinds of heteroduplex similarity observed among animal viruses are reminiscent of what is found for bacteriophages. Viruses found in widely divergent hosts show much greater similarity than would be expected; quite possibly animal viruses also evolve as a population of interchangeable modules.