Genomic Islands of Uropathogenic Escherichia coli Contribute to Virulence
Genomic Islands of Uropathogenic Escherichia coli Contribute to Virulence
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DOI：
10.1128/jb.01717-08
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发表时间：
2009-06-01
影响因子：
3.2
通讯作者：
Mobley, Harry L. T.
中科院分区：
文献类型：
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作者：
Lloyd, Amanda L.;Henderson, Tiffany A.;Mobley, Harry L. T.
尿路致病性大肠杆菌（UPEC）菌株CFT 073含有13个大小从32 kb至123 kb的大基因组岛。这些基因组岛中的11个从基因组中单独删除，并测试了9个同基因突变体在上行性尿路感染的CBA/J小鼠模型中定殖的能力。三个基因组岛突变体（Δ PAI-aspV、Δ PAI-metV和Δ PAI-asnT）在膀胱和/或肾脏经尿道共同攻击后被野生型CFT 073显著胜过（P
Uropathogenic Escherichia coli (UPEC) strain CFT073 contains 13 large genomic islands ranging in size from 32 kb to 123 kb. Eleven of these genomic islands were individually deleted from the genome, and nine isogenic mutants were tested for their ability to colonize the CBA/J mouse model of ascending urinary tract infection. Three genomic island mutants (Delta PAI-aspV, Delta PAI-metV, and Delta PAI-asnT) were significantly outcompeted by wild-type CFT073 in the bladders and/or kidneys following transurethral cochallenge (P