Molecular and Functional Expression of Voltage‐Operated Calcium Channels During Osteogenic Differentiation of Human Mesenchymal Stem Cells

Molecular and Functional Expression of Voltage‐Operated Calcium Channels During Osteogenic Differentiation of Human Mesenchymal Stem Cells
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DOI：
10.1359/jbmr.050521
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发表时间：
2005-09
期刊：
Journal of Bone and Mineral Research
影响因子：
6.2
通讯作者：
I. Zahanich;E. Graf;J. Heubach;U. Hempel;S. Boxberger;U. Ravens
I. Zahanich;E. Graf;J. Heubach;U. Hempel;S. Boxberger;U. Ravens
中科院分区：
医学1区
文献类型：
--
作者：
I. Zahanich;E. Graf;J. Heubach;U. Hempel;S. Boxberger;U. Ravens

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We used the patch‐clamp technique and RT‐PCR to study the molecular and functional expression of VOCCs in undifferentiated hMSCs and in cells undergoing osteogenic differentiation. L‐type Ca2+ channel blocker nifedipine did not influence alkaline phosphatase activity, calcium, and phosphate accumulation of hMSCs during osteogenic differentiation. This study suggests that osteogenic differentiation of hMSCs does not require L‐type Ca2+ channel function.