OLIVOPONTOCEREBELLAR ATROPHY - A REVIEW OF 117 CASES
OLIVOPONTOCEREBELLAR ATROPHY - A REVIEW OF 117 CASES
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DOI：
10.1016/0022-510x(82)90011-9
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发表时间：
1982-01-01
影响因子：
4.4
通讯作者：
BERCIANO, J
中科院分区：
文献类型：
--
作者：
BERCIANO, J
对54例家族性橄榄体桥脑小脑萎缩（FOPCA）和63例散发性OPCA（SOPCA）的发病年龄、病程、症状频率和病变部位进行了评价。FOPCA与SOPCA相比，发病早，病程长（P < 0.001）。临床表现和相关病变的百分比差异也很显著，FOPCA中异常运动、眼肌麻痹、脊柱症状和位于齿状核和脊髓（锥体束除外）的病变的频率更高。回顾了临床体征和症状，特别强调吞咽困难和尿失禁。
Data concerning age at onset, duration of the disease, frequency of symptoms and various localizations of lesions were evaluated in 54 cases of human familial OPCA [olivopontocerebellar atrophy] (FOPCA) and 63 cases of sporadic OPCA (SOPCA) from the literature. In comparison with SOPCA, the disease begins earlier in FOPCA and lasts longer (P < 0.001). Differences in the percentages of clinical manifestations and associated lesions are also significant with regard to the greater frequency in FOPCA of abnormal movements, ophthalmoplegia, spinal symptoms and lesions located in the dentate nucleus and spinal cord, except for the pyramidal tract. The clinical signs and symptoms are reviewed, special emphasis being given to dysphagia and urinary incontinence.