Persistent organochlorine compounds and birth weight
Persistent organochlorine compounds and birth weight
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DOI：
10.1016/s1047-2797(02)00268-5
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发表时间：
2003-03-01
影响因子：
5.6
通讯作者：
Little, RE
中科院分区：
文献类型：
--
作者：
Gladen, BC;Shkiryak-Nyzhnyk, ZA;Little, RE
目的：确定出生体重是否与产前接触持久性有机氯化合物有关。方法：从 1993 年至 1994 年在乌克兰两个城市出生的一般人群中抽取 197 名单胎婴儿，获得出生体重。七种有机氯农药（对，对'-DDT、对，对'-DDE、β-六氯环己烷、六氯苯、反式九氯、出生后四五天的母乳中测得的氯丹、环氧七氯）和 11 种多氯联苯同系物被用作产前暴露指标。 结果：β-六氯环己烷的差异最大，其模式不提示剂量反应；最低三分位数的婴儿较小，中间三分位数的婴儿较大，而上部三分位数的婴儿则中等。调整胎龄和其他潜在混杂因素对这些模式影响不大。 p,p'-DDE 的前两个三分位数中的婴儿比后三分位数中的婴儿更大，调整胎龄后效果更为显着。对潜在混杂因素的调整使这种模式消失了。其他化学物质没有显示出令人信服的影响证据。结论：产前接触所研究的化学物质（以目前在该人群中观察到的浓度）不会影响出生时的体重。
PURPOSE: To determine whether weight at birth is related to prenatal exposure to persistent organochlorine compounds.METHODS: Birth weight was obtained for 197 singleton infants drawn from the general population born in two cities in Ukraine in 1993 to 1994. Concentrations of seven organochlorine pesticides (p,p'-DDT, p,p'-DDE, beta-hexachlorocyclohexane, hexachlorobenzene, trans-nonachlor, oxychlordane, heptachlor epoxide) and 11 polychlorinated biphenyl congeners measured in maternal milk taken at four or five days after birth were used as an index of prenatal exposure.RESULTS: The greatest differences were seen for beta-hexachlorocyclohexane, with a pattern not suggestive of dose-response; infants in the lowest tertile were small, those in the central tertile were large, and those in the upper tertile were average. Adjustment for gestational age and other potential confounders had little effect on these patterns. Infants in the two upper tertiles for p,p'-DDE were larger than those in the lower tertile, with the effect being more striking after adjustment for gestational age. Adjustment for potential confounders made the pattern disappear. Other chemicals showed no convincing evidence of effects.CONCLUSIONS: Prenatal exposure to the chemicals studied, at concentrations currently seen in this population, does not impact weight at birth.