Diagnosis and treatment of invasive group A streptococcal infections.
Diagnosis and treatment of invasive group A streptococcal infections.
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DOI：
10.1517/17530059.2.3.289
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发表时间：
2008-03-01
期刊：
影响因子：
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通讯作者：
Carapetis, Jonathan R
中科院分区：
文献类型：
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作者：
Steer, Andrew C;Curtis, Nigel;Carapetis, Jonathan R
背景：A组侵袭性链球菌感染是一种病死率较高的严重感染。目的：综述目前侵袭性A组链球菌感染的诊断和治疗方法，为其发病机制和流行病学提供背景资料。方法：综述有关A组侵袭性链球菌感染的发病机制、流行病学、诊断和治疗的最新文献。结果/结论：工业化国家的A组侵袭性链球菌感染的发病率约为3/10万，而发展中国家的发病率高出数倍。侵袭性A组链球菌感染的治疗包括支持性护理、手术清除坏死组织、正确使用抗生素、静脉注射免疫球蛋白和接触性预防。最近的研究表明，早期使用静脉注射免疫球蛋白可以减少坏死性筋膜炎根治性清创的需要。
BACKGROUND: Invasive group A streptococcal infections are serious infections that carry a high mortality.OBJECTIVE: The aim was to review current methods of diagnosis and treatment of invasive group A streptococcal infections as well as to provide background on the pathogenesis and epidemiology of these infections.METHODS: The most recent literature regarding pathogenesis, epidemiology, diagnosis and treatment of invasive group A streptococcal infections is reviewed.RESULTS/CONCLUSION: The incidence of invasive group A streptococcal infections in industrialised countries is in the order of 3 per 100,000, whereas in developing countries available evidence suggests that the incidence is several-fold higher. Management of invasive group A streptococcal infections includes supportive care, surgical debridement of necrotic tissue, correct use of antibiotics, intravenous immunoglobulin and contact prophylaxis. Recent studies suggest that the early use of intravenous immunoglobulin may reduce the need for radical debridement of tissue in cases of necrotising fasciitis.