Intestinal microbiome composition and its relation to joint pain and inflammation
Intestinal microbiome composition and its relation to joint pain and inflammation
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DOI：
10.1038/s41467-019-12873-4
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发表时间：
2019-10-25
影响因子：
16.6
通讯作者：
van Meurs, Joyce B. J.
中科院分区：
文献类型：
--
作者：
Boer, Cindy G.;Radjabzadeh, Djawad;van Meurs, Joyce B. J.
巨噬细胞介导的炎症被认为在骨关节炎相关疼痛和严重程度中具有因果作用，并且被认为是由胃肠道微生物群产生的内毒素所引发。在此，我们在鹿特丹研究（一项基于大规模人群的队列研究）中探究关节疼痛与胃肠道微生物群组成以及骨关节炎相关膝关节疼痛之间的关系。我们表明，链球菌属的丰度与膝关节疼痛加剧相关，我们通过对链球菌属的绝对定量进行了验证。此外，我们在生命线 - 深度（Lifelines - DEEP）研究的867名白种人成年人中重复了这些结果。最后，我们证明这种关联是由膝关节局部炎症所驱动。我们的研究结果表明，微生物群是骨关节炎相关膝关节疼痛的一个可能的治疗靶点。
Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain.