Histological investigation of the titanium fiber mesh with one side sealed with non-porous material for its application to the artificial heart system
Histological investigation of the titanium fiber mesh with one side sealed with non-porous material for its application to the artificial heart system
复制标题
一侧密封无孔材料钛纤维网应用于人工心脏系统的组织学研究
DOI：
10.1007/s10047-018-1066-x
复制
发表时间：
2018
影响因子：
1.3
通讯作者：
Mitamura Y
中科院分区：
文献类型：
--
作者：
Okamoto E;Arimura K;Mitamura Y
在这项研究中，我们研究了一种表面用无孔材料密封的钛纤维网状圆盘的组织诱导特性。我们使用烧结钛纤维网（Hi-Lex Co., Zellez™，Hyogo, Japan），钛纤维直径为50µm，钛纤维网的体积孔隙率为87%，平均孔径为200µm。钛纤维网呈圆盘状，直径为5mm，厚度为1.5 mm。将钛纤维网盘一侧用无毒性硅橡胶胶粘剂密封，将密封好的钛纤维网盘植入大鼠背部皮肤下，于术后第4周和第12周取出。我们研究了毛细血管的分布；我们还利用扩散方程估计了氧气从毛细血管扩散的程度。镜下观察毛细血管分布主要局限于密封钛纤维网盘周围区域，密封钛纤维网盘内结缔组织状态较差。通过对氧气从毛细血管扩散的程度的估计，在密封钛纤维网盘的中心可能存在氧气供应不足的区域。综上所述，对于密封钛纤维网应用于人工心脏系统，钛纤维网的厚度是保证内部组织处于健康状态的重要因素。
In this study, we investigated tissue-inducing characteristics of a titanium fiber mesh disk with one surface sealed with a non-porous material. We used sintered titanium fiber mesh (Hi-Lex Co., Zellez™, Hyogo, Japan) having a titanium fiber diameter of 50 µm and volumetric porosity of the titanium fiber mesh of 87% with an average pore size of 200 µm. The titanium fiber mesh is disk-shaped with a dimeter of 5 mm and a thickness of 1.5 mm. One side of the titanium fiber mesh disk was sealed with silicone rubber adhesive that has no venomousness and the sealed titanium fiber mesh disks were implanted in rats under the skin of the dorsal region, and they were extracted in the 4th and 12th postoperative weeks. We investigated the distribution of capillaries; also we estimated the extent of the spread of oxygen from capillaries using the diffusion equation. Microscopic observation showed that the distribution of capillaries was mainly confined to the area around the sealed titanium fiber mesh disk and that connective tissue inside the sealed titanium fiber mesh disk seemed to be in a poor condition. From estimation of the extent of the spread of oxygen from capillaries, an area in which oxygen was poorly supplied may exist in the center of the sealed titanium fiber mesh disk. In conclusion, for application of the sealed titanium fiber mesh to an artificial heart system, the thickness of the titanium fiber mesh is an important factor for keeping the inside tissue in a healthy condition.