Suprachiasmatic nucleus grafts restore circadian function in aged hamsters.
Suprachiasmatic nucleus grafts restore circadian function in aged hamsters.
复制标题
视交叉上核移植可恢复老年仓鼠的昼夜节律功能。
DOI：
10.1016/0006-8993(95)00423-n
复制
发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
Davis,FC
中科院分区：
文献类型：
--
作者：
Viswanathan,N;Davis,FC
昼夜节律的调节随着年龄的增长而变化。对于人类来说，睡眠和觉醒时间的变化尤其常见。在叙利亚仓鼠 Mesocricetus auratus 中，活动/休息节律的自由奔跑期随着年龄的增长而缩短。本研究检验了以下假设：下丘脑视交叉上核（SCN）内发生与年龄相关的关键变化，已知该核含有昼夜节律起搏器。胎儿 SCN 被移植到年幼（20 周）和年长（81 周）仓鼠的大脑中，这些仓鼠自身的 SCN 已被切除。节律性的恢复和节律性的自由运行周期是根据轮运行活动的连续记录来确定的。移植恢复了两个年龄段宿主的节律性。在年老仓鼠中，移植后的平均自由奔跑时间比 SCN 消融前测量的更长，但在年轻仓鼠移植后没有观察到类似的时间延长。此外，即使在 SCN 消融前各组之间存在差异，年轻和年长宿主的移植后平均时间也是相同的。当移植物老化时，恢复节律的平均自由运行时间变短，表明移植物也可能经历与年龄相关的变化。结果表明，与年龄相关的变化，特别是视交叉上核的变化，是造成自由奔跑期与年龄相关的变化的原因。
The regulation of circadian rhythms changes with age. In humans, changes in the timing of sleep and wakefulness are especially common. In Syrian hamsters Mesocricetus auratus the freerunning period of the activity/rest rhythm shortens with age. The present study tested the hypothesis that critical age-related changes occur within the hypothalamic suprachiasmatic nucleus (SCN), known to contain a circadian pacemaker. Fetal SCN were transplanted into the brains of younger (20 weeks) and older (81 weeks) hamsters which had had their own SCNs ablated. The restoration of rhythmicity and the freerunning period of the rhythmicity were determined from continuous records of wheel-running activity. Transplantation restored rhythmicity in hosts of both ages. In older hamsters, the mean freerunning period after transplantation was longer than that measured before SCN ablation, but a similar lengthening of period was not observed after transplantation to younger hamsters. In addition, the mean period after transplantation was the same for both younger and older hosts even when there was a difference between the groups before SCN ablation. When the grafts were allowed to age, the mean freerunning period of the restored rhythms became shorter, indicating that the grafts can also undergo age-related changes. The results indicate that age-related changes specifically in the SCN are responsible for an age-related change in freerunning period.