circMAN1A2 could serve as a novel serum biomarker for malignant tumors
circMAN1A2 could serve as a novel serum biomarker for malignant tumors
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circMAN1A2可以作为恶性肿瘤的新型血清生物标志物
DOI：
10.1111/cas.14034
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发表时间：
2019-07-01
期刊：
影响因子：
5.7
通讯作者：
Zeng, Zhao-Yang
中科院分区：
文献类型：
--
作者：
Fan, Chun-Mei;Wang, Jin-Peng;Zeng, Zhao-Yang
需要新的癌症诊断和预后生物标志物来提高精准医疗。环状rna在癌症的转录和转录后水平上起着重要的调节作用。根据我们之前的RNA测序数据，环状RNA circMAN1A2在鼻咽癌中高表达；然而，circMAN1A2在癌症中的表达和功能仍然不清楚。因此，在本研究中，我们评估了circMAN1A2在鼻咽癌及其他恶性肿瘤患者血清中的表达，并分析了其与临床特征及诊断价值的相关性。采用实时荧光定量PCR检测circMAN1A2的表达水平，chi(2)检验分析临床特征与circMAN1A2表达的相关性。采用受试者工作特征曲线评价circMAN1A2的临床应用。结果显示，circMAN1A2在鼻咽癌、口腔癌、甲状腺癌、卵巢癌和肺癌中表达上调，曲线下面积分别为0.911、0.779、0.734、0.694和0.645，表明circMAN1A2具有良好的诊断价值。总之，我们的研究结果表明circMAN1A2可能是恶性肿瘤的血清生物标志物，为恶性肿瘤的诊断方法提供了重要的见解。circMAN1A2在癌症发病中的作用机制有待进一步研究。
Novel diagnostic and prognostic biomarkers of cancers are needed to improve precision medicine. Circular RNAs act as important regulators in cancers at the transcriptional and posttranscriptional levels. The circular RNA circMAN1A2 is highly expressed in nasopharyngeal carcinoma according to our previous RNA sequencing data; however, the expression and functions of circMAN1A2 in cancers are still obscure. Therefore, in this study, we evaluated the expression of circMAN1A2 in the sera of patients with nasopharyngeal carcinoma and other malignant tumors and analyzed its correlations with clinical features and diagnostic values. The expression levels of circMAN1A2 were detected by quantitative real-time PCR, and the correlations of clinical features with circMAN1A2 expression were analyzed by chi(2) tests. Receiver operating characteristic curves were used to evaluate the clinical applications of circMAN1A2. The results showed that circMAN1A2 was upregulated in nasopharyngeal carcinoma, oral cancer, thyroid cancer, ovarian cancer, and lung cancer, with areas under the curves of 0.911, 0.779, 0.734, 0.694, and 0.645, respectively, indicating the good diagnostic value of circMAN1A2. Overall, our findings suggested that circMAN1A2 could be a serum biomarker for malignant tumors, providing important insights into diagnostic approaches for malignant tumors. Further studies are needed to elucidate the mechanisms of circMAN1A2 in the pathogenesis of cancer.