EFFECT OF A NOVEL SOFT STEROID ON THE WOUND-HEALING OF RABBIT CORNEA
EFFECT OF A NOVEL SOFT STEROID ON THE WOUND-HEALING OF RABBIT CORNEA
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DOI：
10.1016/0014-4835(90)90229-n
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发表时间：
1990-02-01
影响因子：
3.4
通讯作者：
VARGA, M
中科院分区：
文献类型：
--
作者：
BODOR, N;VARGA, M
本文研究了一种“软”抗炎皮质类固醇对兔角膜创伤愈合的影响。白化病兔行角膜线性穿孔切口后，用软性类固醇和地塞米松治疗。软药物的目的是控制和指导药物活性和体内代谢为无毒部分。这些药物在进入全身循环后迅速失活。在具有良好的局部活性的同时，它们因此具有高的治疗指数而没有全身副作用。通过组织学定性评价伤口愈合过程。显微照片显示，除了其有利的代谢特性，软类固醇在最大限度地减少瘢痕形成方面与地塞米松一样有效或更有效。这种软类固醇可以是局部应用的有效抗炎和抗过敏剂，而没有传统药物的大多数不需要的活性，通过故意简化它们的处置。
The effect of a ''soft'' anti-inflammatory corticosteroid on the corneal wound healing was investigated in rabbits. Albino rabbits were treated with soft steroid and dexamethasone after linear perforating corneal incision. Soft drug is aimed to control and direct the drug activity and in vivo metabolism to non-toxic moieties. These drugs are rapidly deactivated after they reach the general circulation. While having good local activity, they thus possess high therapeutic indexes without systemic side effects. The wound healing process was evaluated qualitatively by histology. Photomicrographs are presented to show that the soft steroid is as or more effective than dexamethasone in minimizing scarring in addition to its advantageous metabolic properties. This soft steroid may be an efficient anti-inflammatory and anti-allergic agent in topical application without the majority of unwanted activities of traditional drugs by deliberately simplifying their disposition.