On the mechanism of energy transduction in myosin subfragment 1.
On the mechanism of energy transduction in myosin subfragment 1.
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肌球蛋白亚片段能量传导机制1.
DOI：
10.1073/pnas.81.7.2060
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发表时间：
1984
影响因子：
11.1
通讯作者：
Morales,MF
中科院分区：
文献类型：
--
作者：
Botts,J;Takashi,R;Torgerson,P;Hozumi,T;Muhlrad,A;Mornet,D;Morales,MF
有人提出，肌球蛋白亚片段1部分的肌肉收缩装置是一个独立的“引擎”，其操作计划是基于ATP（或降解中间体）的结合和肌动蛋白结合的相互作用的性质，使之可能通过一个intersite通信系统。有人建议，检查这个引擎所需的空间信息可以，至少暂时，来自荧光共振能量转移测量的Förster方程解释和存在的站点间通信系统可以推断从分段检测相互作用的点对。
It is proposed that the myosin subfragment 1 moiety of the muscle contractile apparatus is a self-contained "engine" whose operational plan is based on the interactive nature of ATP (or degradation intermediate) binding and actin binding, made possible by an intersite communication system. It is suggested that the spatial information required for examining this engine can, at least provisionally, be derived from fluorescence resonance energy transfer measurements interpreted by the Förster equation and that the existence of an intersite communication system can be deduced from piece-wise detection of interacting pairs of points.