Decreased motor cortex γ-aminobutyric acid in amyotrophic lateral sclerosis
Decreased motor cortex γ-aminobutyric acid in amyotrophic lateral sclerosis
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DOI：
10.1212/wnl.0b013e3182563b57
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发表时间：
2012-05-01
期刊：
影响因子：
9.9
通讯作者：
Feldman, E. L.
中科院分区：
文献类型：
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作者：
Foerster, B. R.;Callaghan, B. C.;Feldman, E. L.
目的：使用质子磁共振波谱（H-1-MRS）确定肌萎缩侧索硬化症（ALS）患者与健康对照组相比运动皮层和皮层下白色物质中γ-氨基丁酸（GABA）是否存在体内差异。在这项横断面研究中，10名ALS患者和9名年龄和性别匹配的健康对照（HC）接受了3 T编辑的H-1-MRS，以量化运动皮层和皮层下白色物质的GABA。与健康对照组相比，ALS患者左侧运动皮层的GABA水平显著降低（1.42 +/- 0.27任意机构单位vs 1.70 +/- 0.24任意机构单位，p = 0.038）。皮质下白色物质中GABA水平组间无显著差异（p > 0.05）。结论：ALS患者运动皮质中GABA水平较HC降低。研究结果与先前报道的运动皮层中GABA受体的改变以及ALS背景下皮质兴奋性增加一致。需要更大规模的纵向研究来证实这些发现，并进一步了解GABA在ALS发病机制中的作用。神经病学（R）2012;78：1596-1600
Objectives: To determine if there are in vivo differences in gamma-aminobutyric acid (GABA) in the motor cortex and subcortical white matter of patients with amyotrophic lateral sclerosis (ALS) compared with healthy controls using proton magnetic resonance spectroscopy (H-1-MRS).Methods: In this cross-sectional study, 10 patients with ALS and 9 age-and sex-matched healthy controls (HCs) underwent 3T edited H-1-MRS to quantify GABA centered on the motor cortex and the subcortical white matter.Results: Compared with healthy controls, patients with ALS had significantly lower levels of GABA in the left motor cortex (1.42 +/- 0.27 arbitrary institutional units vs 1.70 +/- 0.24 arbitrary institutional units, p = 0.038). There was no significant difference in GABA levels between groups in the subcortical white matter (p > 0.05).Conclusion: Decreased levels of GABA are present in the motor cortex of patients with ALS compared to HCs. Findings are consistent with prior reports of alterations in GABA receptors in the motor cortex as well as increased cortical excitability in the context of ALS. Larger, longitudinal studies are needed to confirm these findings and to further our understanding of the role of GABA in the pathogenesis of ALS. Neurology (R) 2012;78:1596-1600