The postnatal maternal environment influences diabetes development in nonobese diabetic mice.
The postnatal maternal environment influences diabetes development in nonobese diabetic mice.
复制标题
产后母体环境影响非肥胖糖尿病小鼠的糖尿病发展。
DOI：
10.1016/j.jaut.2006.11.006
复制
发表时间：
2007
影响因子：
12.8
通讯作者：
Kaufman,DL
中科院分区：
文献类型：
--
作者：
Washburn,LR;Dang,H;Tian,J;Kaufman,DL
When nonobese-diabetic (NOD) mouse embryos were implanted into pseudopregnant mothers of a nonautoimmune mouse strain, the progeny had a reduced type 1 diabetes (T1D) incidence, suggesting that transmission of maternal autoantibodies is important for T1D development. Whether eliminating islet autoantibody transmission in utero, or postnatally (through milk), prevented T1D is unknown. Herein, we show that fostering newborn NOD mice on B-cell deficient NOD.Igμ−/− dams does not prevent T1D, demonstrating that postnatally transmitted islet autoantibodies are not required for disease pathogenesis. Additionally, NOD.Igμ−/− mice reared on NOD dams did not develop T1D, indicating that autoantibody transmission to B-cell deficient NOD neonates is insufficient to trigger T1D. Interestingly, newborn NOD mice that were reared by ICR (but not NOD or C57BL/6) dams had reduced T1D incidence, although not as reduced as that reported after embryo transfer to ICR mice, suggesting that both prenatal and postnatal factors contribute to the observed reduction in T1D incidence. Thus, NOD mice have different risks for developing T1D depending on the strain of their foster mother, and both prenatal and postnatal maternal factors, other than islet autoantibodies, influence their T1D incidence. The results may be relevant for understanding the increasing incidence of T1D and designing interventions.
登录
查看更多内容
胎儿循环中 1 型糖尿病相关抗体：1 型糖尿病母亲后代的患病率及其对脐带胰岛素和出生体重的影响。
影响因子：
5.8
作者：
Robert Lindsay;Anette;B. Hamilton;Andrew A. Calder;Frank D. Johnstone;James D. Walker
通讯作者：
James D. Walker
影响因子：
7.7
作者：
Harrison, LC;Honeyman, MC
通讯作者：
Honeyman, MC
基于抗原的免疫疗法推动自身免疫的早熟发展1
影响因子：
4.4
作者：
Jide Tian;A. Olcott;D. Kaufman
通讯作者：
D. Kaufman
患有 1 型糖尿病的父母的后代中与短暂母体获得性胰岛抗体和持久性胰岛抗体相关的患病率、特征和糖尿病风险。
影响因子：
5.8
作者：
H. Naserke;E. Bonifacio;A. Ziegler
通讯作者：
A. Ziegler
影响因子：
4.4
作者：
Tian, J;Zekzer, D;Kaufman, DL
通讯作者：
Kaufman, DL