Long-term oxytocin administration improves social behaviors in a girl with autistic disorder.
Long-term oxytocin administration improves social behaviors in a girl with autistic disorder.
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DOI：
10.1186/1471-244x-12-110
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发表时间：
2012-08-13
期刊：
影响因子：
4.4
通讯作者：
Wada Y
中科院分区：
文献类型：
--
作者：
Kosaka H;Munesue T;Ishitobi M;Asano M;Omori M;Sato M;Tomoda A;Wada Y
自闭症谱系障碍 (ASD) 患者表现出核心自闭症症状，包括童年时期的社交障碍，并且大多数表现出继发性残疾，例如基于核心症状的烦躁和攻击行为。然而，这些患者的社交障碍仍然没有根治性的治疗方法。据报道，催产素在依赖于社会认可的多种社会行为中发挥着重要作用，并有望成为自闭症谱系障碍患者社交障碍的有效治疗方法之一。我们介绍了一名患有自闭症的 16 岁女孩，她长期服用催产素鼻喷雾剂进行治疗。经过两个月的治疗，她的自闭症症状得到了成功治愈；女孩的社交互动和社交沟通开始改善，没有产生不利影响。她的烦躁和攻击行为也显着改善，异常行为检查表分数从 69 分显着下降到 7 分。该病例首次说明长期使用催产素鼻喷雾剂有针对性地治疗患有自闭症的女性的社交障碍。该病例表明，长期鼻用催产素喷雾剂对于治疗自闭症谱系障碍患者的社交障碍有希望且耐受性良好。
Patients with autism spectrum disorders (ASDs) exhibit core autistic symptoms including social impairments from early childhood and mostly show secondary disabilities such as irritability and aggressive behavior based on core symptoms. However, there are still no radical treatments of social impairments in these patients. Oxytocin has been reported to play important roles in multiple social behaviors dependent on social recognition, and has been expected as one of the effective treatments of social impairments of patients with ASDs. We present a case of a 16-year-old girl with autistic disorder who treated by long-term administration of oxytocin nasal spray. Her autistic symptoms were successfully treated by two month administration; the girl’s social interactions and social communication began to improve without adverse effects. Her irritability and aggressive behavior also improved dramatically with marked decreases in aberrant behavior checklist scores from 69 to 7. This case is the first to illustrate long-term administration of oxytocin nasal spray in the targeted treatment of social impairments in a female with autistic disorder. This case suggests that long-term nasal oxytocin spray is promising and well-tolerated for treatment of social impairments of patients with ASDs.