Multi- and trans-generational disturbances of perfluorobutane sulfonate and perfluorohexane sulfonate on lipid metabolism in Caenorhabditis elegans
Multi- and trans-generational disturbances of perfluorobutane sulfonate and perfluorohexane sulfonate on lipid metabolism in Caenorhabditis elegans
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全氟丁烷磺酸盐和全氟己烷磺酸盐对秀丽线虫脂代谢的多代和跨代干扰
DOI：
10.1016/j.chemosphere.2021.130666
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发表时间：
2021-05-01
期刊：
影响因子：
8.8
通讯作者：
Yin, Daqiang
中科院分区：
文献类型：
--
作者：
Li, Zhuo;Yu, Zhenyang;Yin, Daqiang
短链全氟丁烷磺酸盐（PFBS，four-carbon）和全氟己烷磺酸盐（PFHxS，six-carbon）被广泛用于取代长链全氟烷基和多氟烷基物质（PFASs）。最近的研究表明PFBS和PFHxS的潜在持久性，并报告了它们与肥胖的相关性。然而，长期结果和潜在机制仍然知之甚少。目前，研究了PFBS和PFHxS对C.进行多代和跨代实验的优雅动物。在连续四代暴露中测量多代效应（即，F1至F4）。结果表明，PFBS对F1代脂肪含量无明显影响，但对F4代脂肪代谢和胰岛素及胰岛素样（IIS）途径有不同程度的持续干扰。PFHxS刺激F1和F4的脂肪含量，对脂质代谢和IIS途径的干扰相似。跨代结果表明，PFBS和PFHxS对F1后代的脂质代谢和IIS途径的影响并未完全恢复（即，T1 -T3）和F4（即，T1 ′-T3 ′）。PFHxS在多代和跨代效应中都表现出上调daf-7的共同模式。短链PFASs替代品的长期影响应引起关注，在未来的机制研究中应考虑表观遗传调控。(C)2021爱思唯尔有限公司版权所有。
Short-chained perfluorobutane sulfonate (PFBS, four-carbon) and perfluorohexane sulfonate (PFHxS, sixcarbon) are widely employed to substitute long-chained per- and poly-fluoroalkyl substances (PFASs). Recent studies showed the potential persistence of PFBS and PFHxS, and also reported their correlation with obesity. However, the long-term outcome and underlying mechanisms remained poorly understood. Presently, the effects of PFBS and PFHxS were studied on C. elegans with multi- and trans-generational experiments. The multi-generational effects were measured in continuous four generational exposure (i.e., F1 to F4). Results showed that PFBS did not stimulate the fat content in F1 but in F4 with continuous but different disturbances on the lipid metabolism and the insulin and insulin-like (IIS) pathway. PFHxS stimulated the fat content in F1 and F4 with similar disturbances on the lipid metabolism and IIS pathway. The trans-generational results showed that the effects of PFBS and PFHxS on the lipid metabolism and IIS pathway were not totally recovered in the offspring of F1 (i.e., T1 -T3) and F4 (i.e., T1'-T3') which were not continuously exposed. PFHxS showed a common pattern to up-regulate daf-7 in both multi- and trans-generational effects. The long-term consequences of the short-chained PFASs substitutes should be concerned and epigenetic regulations should be considered in future mechanism studies. (C) 2021 Elsevier Ltd. All rights reserved.