Personality Traits Share Overlapping Neuroanatomical Correlates With Internalizing and Externalizing Psychopathology
Personality Traits Share Overlapping Neuroanatomical Correlates With Internalizing and Externalizing Psychopathology
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DOI：
10.1037/abn0000391
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发表时间：
2019-01-01
影响因子：
4.6
通讯作者：
Miller, Joshua D.
中科院分区：
文献类型：
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作者：
Hyatt, Courtland S.;Owens, Max M.;Miller, Joshua D.
虽然人格特质与内化和外化精神病理学有关，但这些特质和精神病理表型在多大程度上共享共同的神经解剖结构尚不清楚。为了解决这一差距，我们使用结构神经成像和自我报告的数据，从1101名参与者在人类连接组计划，以生成神经解剖学档案（NAPS）的FFM特征和精神病理学指数组成的厚度，表面积，和祈祷物质体积的每个区域在Desikan地图集，然后使用配置文件匹配的方法来比较的FFM特征NAP和精神病理学指数NAP的绝对相似性。这些分析表明，来自神经质和外倾性的NAP表现出中等到大的积极和消极的绝对相似性，内化精神病理学的NAP，分别。同样，责任心和尽责性的NAP分别与反社会行为和物质使用的NAP呈中度至重度负相关。这些结果表明，类似的神经解剖学相关的基础上特定的人格特质和精神病理学的症状，将人格特质的病因和精神病理学的表现维度模型提供支持。
Although personality traits have been linked to internalizing and externalizing psychopathology, the extent to which these traits and psychopathological phenotypes share a common neuroanatomical structure is unclear. To address this gap, we used structural neuroimaging and self-report data from 1101 participants in the Human Connectome Project to generate neuroanatomical profiles (NAPS) of FFM traits and psychopathology indices composed of the thickness, surface area, and pray matter volume of each region in the Desikan atlas, then used a profile matching approach to compare the absolute similarity of the FFM trait NAPs and psychopathology index NAPs. These analyses indicated that the NAPs derived from Neuroticism and Extraversion demonstrated medium to large positive and negative absolute similarities to the NAPs of internalizing psychopathology, respectively. Similarly, the NAPs of Agreeableness and Conscientiousness showed medium to large negative, relations with the, NAPs of antisocial behavior and substance use, respectively. These results suggest that similar neuroanatomical correlates underlie specific personality traits and symptoms of psychopathology, providing support for dimensional models that incorporate personality traits into the etiology and manifestation of psychopathology.