Toll-Like Receptor 2 Signaling and Current Approaches for Therapeutic Modulation in Synucleinopathies.
Toll-Like Receptor 2 Signaling and Current Approaches for Therapeutic Modulation in Synucleinopathies.
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DOI：
10.3389/fphar.2018.00417
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发表时间：
2018
影响因子：
5.6
通讯作者：
Maguire-Zeiss KA
中科院分区：
文献类型：
--
作者：
Caplan IF;Maguire-Zeiss KA
中枢神经系统（CNS）的先天免疫反应对健康既有益又有害。在这个过程中不可或缺的是小胶质细胞，它是中枢神经系统的常驻免疫细胞。小胶质细胞表达各种各样的模式识别受体，如toll样受体，检测神经环境的变化。小胶质细胞的激活和随后的促炎反应与突触核蛋白病越来越相关，包括帕金森病（第二大最常见的神经退行性疾病）。在这些疾病中，有证据表明内源性α-突触核蛋白的积累通过toll样受体刺激小胶质细胞的炎症反应。最近有新的和旧的药理学药物的发展，旨在针对小胶质细胞和减少炎症环境。这篇综述将旨在描述小胶质细胞介导的炎症过程和新的治疗途径来管理反应。
The innate immune response in the central nervous system (CNS) is implicated as both beneficial and detrimental to health. Integral to this process are microglia, the resident immune cells of the CNS. Microglia express a wide variety of pattern-recognition receptors, such as Toll-like receptors, that detect changes in the neural environment. The activation of microglia and the subsequent proinflammatory response has become increasingly relevant to synucleinopathies, including Parkinson's disease the second most prevalent neurodegenerative disease. Within these diseases there is evidence of the accumulation of endogenous α-synuclein that stimulates an inflammatory response from microglia via the Toll-like receptors. There have been recent developments in both new and old pharmacological agents designed to target microglia and curtail the inflammatory environment. This review will aim to delineate the process of microglia-mediated inflammation and new therapeutic avenues to manage the response.
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DOI：
10.3233/jpd-179001
发表时间：
2017
期刊：
Journal of Parkinson's disease
影响因子：
--
作者：
Braak H;Del Tredici K
通讯作者：
Del Tredici K
影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
4.8
作者：
Bala, Shashi;Marcos, Miguel;Szabo, Gyongyi
通讯作者：
Szabo, Gyongyi
影响因子：
4.1
作者：
Bartels, A. L.;Willemsen, A. T. M.;Leenders, K. L.
通讯作者：
Leenders, K. L.
影响因子：
6.4
作者：
Cardoso, Ana L.;Guedes, Joana R.;Pedroso de Lima, Maria C.
通讯作者：
Pedroso de Lima, Maria C.