Multiple groups of endogenous betaretroviruses in mice, rats, and other mammals
Multiple groups of endogenous betaretroviruses in mice, rats, and other mammals
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DOI：
10.1128/jvi.78.11.5784-5798.2004
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发表时间：
2004-06-01
影响因子：
5.4
通讯作者：
Mager, DL
中科院分区：
文献类型：
--
作者：
Baillie, GJ;van de Lagemaat, LN;Mager, DL
β逆转录病毒以内源性和外源性形式存在于宿主体内，分布广泛且在进化上关系较远。在这里，我们报告了小家鼠和褐家鼠基因组中几个以前未知的β逆转录病毒群的发现和表征。每个组都包含小鼠和大鼠元件，其中几个组与先前已知的来自非鼠宿主的β逆转录病毒关系更密切。其中一些群体还包括来自以前不知道携带β逆转录病毒的宿主的成员，例如灰鼠狐猴（Microcebus murinus）和塞巴短尾蝙蝠（Carollia perspicillata）。一些小鼠和大鼠元件具有gag、pro、pol和/或env基因的完整开放阅读框，并显示出最近逆转录的特征。我们提出了一个模型，根据该模型，β逆转录病毒至少在过去2000万年里一直在鼠科啮齿动物的基因组中进化，并且在其鼠科宿主在全球传播之后（或同时），偶尔会传播到其他物种。
Betaretroviruses exist in endogenous and exogenous forms in hosts that are widely distributed and evolutionarily distantly related. Here we report the discovery and characterization of several previously unknown betaretrovirus groups in the genomes of Mus musculus and Rattus norvegicus. Each group contains both mouse and rat elements, and several of the groups are more closely related to previously known betaretroviruses from nonmurine hosts. Some of the groups also include members from hosts which were not previously known to harbor betaretroviruses, such as the gray mouse lemur (Microcebus murinus) and Seba's short-tailed bat (Carollia perspicillata). Some of the mouse and rat elements possess intact open reading frames for gag, pro, pol, and/or env genes and display characteristics of having retrotransposed recently. We propose a model whereby betaretroviruses have been evolving within the genomes of murid rodents for at least the last 20 million years and, subsequent to (or concomitant with) the global spread of their murid hosts, have occasionally been transmitted to other species.