Tolerance induced by IL-6 deficient donor heart is significantly involved in myeloid-derived suppressor cells (MDSCs)
Tolerance induced by IL-6 deficient donor heart is significantly involved in myeloid-derived suppressor cells (MDSCs)
复制标题
IL-6 缺陷供体心脏诱导的耐受性与骨髓源性抑制细胞 (MDSC) 显着相关。
DOI：
10.1016/j.trim.2015.02.001
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发表时间：
2015-03-01
影响因子：
1.5
通讯作者：
Liu, Dahai
中科院分区：
文献类型：
--
作者：
Gong, Weihua;Shou, Dawei;Liu, Dahai
目的：IL-6 缺陷供体诱导的移植耐受得到调节性 T 细胞 (Treg) 的支持。然而，尚不清楚先天免疫调节细胞如骨髓源性抑制细胞 (MDSC) 是否参与该过程。材料和方法：在本研究中，我们通过将 IL-6 缺陷型心脏移植物移植到小鼠同种异体移植模型中的野生型受体中，证明了 MDSC 的作用。结果：我们的数据进一步表明，利用 IL-6 缺陷型心脏移植物可以显着延长同种异体移植物的存活时间（Mantel-Cox 检验，p = 0.001；Gehan-Breslow-Wilcoxon 检验，p = 0.0016），受者脾脏中 CD11b + Gr1(-low) 的频率显着增加 (p = 0.0028)。 结论：MDSC 而不是 Th17 细胞密切参与 IL-6 缺陷供体心脏诱导的耐受性，这揭示了靶向 IL-6 或其信号通路可能为预防非致敏移植受者的同种异体移植排斥提供新的见解。 (C) 2015 Elsevier B.V. 保留所有权利。
Objectives: Transplant tolerance induced by IL-6 deficient donor is supported by regulatory T cells (Tregs). However, it is unknown whether innate immunoregulatory cells such as myeloid-derived suppressor cells (MDSCs) are involved in the process.Materials and methods: In this study, we demonstrate the role of MDSCs by transplanting IL-6 deficient heart grafts into wild-type recipients in a murine allogeneic transplant model.Results: Our data further revealed that utilization of IL-6 deficient heart grafts could cause a significant prolongation of allograft survival (Mantel-Cox Test, p = 0.001; Gehan-Breslow-Wilcoxon Test, p = 0.0016) and a remarkable increase of the frequency of CD11b + Gr1(-low) in the recipients' spleens (p = 0.0028).Conclusions: MDSCs rather than Th17 cells are closely involved in induced tolerance by IL-6 deficient donor heart This unveiled mechanism of targeting IL-6 or its signaling pathway may provide a novel insight into preventing allograft rejection for non-sensitized transplant recipients. (C) 2015 Elsevier B.V. All rights reserved.