Asymmetrical intersection btween the middle cerebral artery and rhinal vein suggests asymmetrical gustatory cortex location in rodent hemispheres
Asymmetrical intersection btween the middle cerebral artery and rhinal vein suggests asymmetrical gustatory cortex location in rodent hemispheres
复制标题
大脑中动脉和鼻静脉之间的不对称交叉表明啮齿动物半球的味觉皮层位置不对称
DOI：
10.1016/j.neulet.2015.01.017
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发表时间：
2015
影响因子：
2.5
通讯作者：
Y.
中科院分区：
文献类型：
--
作者：
Kida;I.;Enmi;J.;Iida;H. and Yoshioka;Y.
啮齿动物的味觉皮质位于岛叶皮质的前部，靠近鼻静脉(RHV)的背部和大脑中动脉(MCA)的前后交界处。因此，RHV和MCA之间的交叉点被用作啮齿动物味觉皮质的标志物。在我们之前的研究中，我们使用功能磁共振成像(MRI)来证明，品尝者在啮齿类动物的岛叶皮质中诱发双边反应，但这些表现在两个半球之间是不对称的。在本研究中，为了阐明观察到的不对称反应，我们在7.0特斯拉MRI扫描仪上进行了磁共振血管成像，以确定啮齿动物味觉皮质的解剖位置，这是使用MCA和RHV的交叉点来识别的。我们在吸入气体Carbogen的同时成功地观察到了交叉点，发现与右半球相比，左半球的交叉点更前移。结合先前的功能MRI结果，这一结果表明，与交叉点相关的味觉表征在两侧大脑半球的岛叶皮质中可能是相同保守的，因此，啮齿动物的味觉皮质可能不对称地位于左右半球之间。这一结果还表明，在研究味觉表征和反应时，这一里程碑式的位置需要得到验证。
The rodent gustatory cortex is located in the anterior part of the insular cortex, which is near the dorsal part of the rhinal vein (RHV) and the intersection of the anterior and posterior regions of the middle cerebral artery (MCA). Thus, the intersection between the RHV and MCA is used as a landmark for the rodent gustatory cortex. In our previous study, we employed functional magnetic resonance imaging (MRI) to demonstrate that tastants evoked bilateral responses in the rodent insular cortices, but that these representations were asymmetrical between the hemispheres. In the present study, to clarify the observed asymmetrical responses, we performed magnetic resonance angiography in a 7.0-Tesla MRI scanner to determine the anatomical position of the rodent gustatory cortex, which was identified using the intersection of the MCA and RHV. We successfully observed the intersection while administering carbogen as an inhaled gas and found that the intersection in the left hemisphere is more anterior compared to that in the right hemisphere. Taken together with the previous functional MRI results, this result indicates that the gustatory representation in relation to the intersection may be identically conserved in the insular cortex of both hemispheres; therefore, the rodent gustatory cortex may be asymmetrically located between the left and right hemispheres. The result also suggests that this landmark location needs to be verified when investigating gustatory representations and responses.