Relation of urinary sodium excretion to blood pressure, glucose metabolism, and lipid metabolism in residents of an area of Japan with high sodium intake.
Relation of urinary sodium excretion to blood pressure, glucose metabolism, and lipid metabolism in residents of an area of Japan with high sodium intake.
复制标题
日本高钠摄入地区居民尿钠排泄与血压、糖代谢和脂质代谢的关系。
DOI：
10.1291/hypres.20.287
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
K. Hiramori
中科院分区：
文献类型：
--
作者：
M. Kawamura;Y. Kimura;K. Takahashi;N. Satoh;K. Oku;T. Adachi;J. Nakajima;M. Murooka;T. Fujiwara;K. Hiramori
为了评估长期摄入高钠饮食对葡萄糖和脂质代谢的影响，我们检查了 140 名日本成年人的每日尿钠排泄量与血压、葡萄糖代谢和脂质代谢的关系，这些成年人居住在过去 15 年平均每日钠消耗量较高且稳定的地区；没有受试者接受过任何高血压或代谢紊乱的治疗。每个受试者均进入我们的健康体检中心进行2天的血压测量、抽血和糖耐量检测。出院后收集每位受试者的 24 小时尿液样本。多元回归分析显示，尿钠排泄量显着独立于平均血压，并且与施用葡萄糖后的血清葡萄糖曲线下面积无关。尿钠水平也与低密度脂蛋白胆固醇和高密度脂蛋白胆固醇无关。每日排钠量低于140毫当量组（低钠组）高血压患病率为0%，而每日排钠量高于280毫当量组（高钠组）高血压患病率为44%；这种差异是显着的（p < 0.01）。两组之间代谢紊乱的患病率没有观察到显着差异。我们的结果表明，钠摄入量对葡萄糖和脂质代谢影响不大，但对居住在钠摄入量相对较高地区的血压正常和未经治疗的高血压受试者的血压有显着影响。
To evaluate the effects of prolonged intake of a high-sodium diet on glucose and lipid metabolism, we examined the relation of daily urinary sodium excretion to blood pressure, glucose metabolism, and lipid metabolism in 140 Japanese adults who lived in a region where the average daily consumption of sodium was high and stable during the past 15 yr; no subject had received any treatment for hypertension or metabolic disorders. Each subject was admitted to our health examination center for 2 d for measurement of blood pressure, sampling of blood, and glucose tolerance testing. A 24-h urine specimen was collected by each subject after discharge. Multiple regression analysis revealed that urinary sodium excretion was significantly independent of the mean blood pressure and was unrelated to the area under the serum glucose curve after glucose administration. The urinary sodium level was also unrelated to low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. The prevalence of hypertension in the group with a daily sodium excretion below 140 mEq (low sodium group) was 0%, while that in the group with a daily sodium excretion above 280 mEq (high sodium group) was 44%; this difference was significant (p < 0.01). No significant difference was observed in the prevalence of metabolic disorders between the two groups. Our results suggest that sodium intake has little influence on glucose and lipid metabolism but has a significant influence on blood pressure in normotensive and untreated hypertensive subjects who reside in an area with a relatively high sodium intake.
影响因子：
3.2
作者：
EGAN, BM;WEDER, AB;HOFFMAN, RG
通讯作者：
HOFFMAN, RG
影响因子：
8.3
作者：
ALDERMAN, MH;MADHAVAN, S;LARAGH, JH
通讯作者：
LARAGH, JH