Modeling ionizing radiation-induced cardiovascular dysfunction with human iPSC-derived engineered heart tissues.
Modeling ionizing radiation-induced cardiovascular dysfunction with human iPSC-derived engineered heart tissues.
复制标题
使用人类 iPSC 衍生的工程心脏组织模拟电离辐射引起的心血管功能障碍。
DOI：
10.1016/j.yjmcc.2023.11.012
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发表时间：
2024
影响因子：
5
通讯作者：
Wu,JosephC
中科院分区：
文献类型：
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作者：
Cao,Xu;Thomas,Dilip;Whitcomb,LukeA;Wang,Mingqiang;Chatterjee,Anushree;Chicco,AdamJ;Weil,MichaelM;Wu,JosephC
长期暴露于核灾难和太空旅行产生的低剂量辐射对人类构成越来越大的重大健康风险。虽然核灾难期间的意外照射往往涉及急性高剂量辐射和慢性低剂量率辐射的混合，难以预测，但空间环境含有持续的低剂量率辐射，这已被证明会增加心血管疾病的风险[1-3]。低地球轨道以外的宇航员暴露于银河宇宙辐射（GCR），包括高电荷，高能（HZE）原子核和高能质子，以及太阳粒子事件（SPE），主要由低和中能量质子组成。这些粒子和它们与航天器和机组人员相互作用产生的二次辐射导致辐射场具有广泛的线性能量转移（LET）。虽然由于高LET暴露具有更大的生物学效应而引起了相当大的关注，但重要的是要注意
Long-term exposure to low-dose radiation from nuclear disasters and space travel poses an increasing and significant health risk to humans. While accidental exposures during nuclear disaster often involve a mixture of acute high-dose and chronic low-dose rate radiation that is hard to predict, the space environment contains constant low-dose rate radiation which has been shown to increase the risk of cardiovascular diseases [1–3]. Astronauts beyond low Earth orbit are exposed to Galactic Cosmic Radiation (GCR) consisting of high-charge, high-energy (HZE) atomic nuclei and high-energy protons, as well as Solar Particle Events (SPE) consisting mostly of low and medium-energy protons. These particles and secondary radiations generated from their interactions with the spacecraft and crew result in a radiation field with a wide range of linear energy transfer (LET). While there is considerable concern about high LET exposures due to their greater biological effectiveness, it is important to note