Epigenetic patterns associated with the immune dysregulation that accompanies psychosocial distress.
Epigenetic patterns associated with the immune dysregulation that accompanies psychosocial distress.
复制标题
DOI：
10.1016/j.bbi.2010.12.002
复制
发表时间：
2011-07
影响因子：
15.1
通讯作者：
Janusek, Linda Witek
中科院分区：
文献类型：
--
作者：
Mathews, Herbert L.;Konley, Teresa;Kosik, Kelly Loster;Krukowski, Karen;Eddy, Justin;Albuquerque, Kevin;Janusek, Linda Witek
社会心理困扰介导的免疫失调的分子基础尚不清楚。本研究的目的是确定外周血单核细胞 (PBMC) 表观遗传模式是否与这种形式的免疫失调相关。新诊断出患有早期乳腺癌的女性被纳入研究，并在诊断时和四个月后完成癌症治疗后进行心理社会、免疫学和表观遗传学评估。在诊断时，女性报告感觉到压力、焦虑和情绪紊乱增加，这些女性的 PBMC 表现出自然杀伤细胞活性降低和干扰素 γ 产生减少，这与治疗完成后获得的结果形成鲜明对比。在表观遗传水平上，与完成治疗后衍生的类似细胞相比，诊断时源自女性的 PBMC 子集表现出独特的表观遗传模式，组蛋白残基 H4-K8 和 H4-K12 的核乙酰化减少，以及 H3-S10 磷酸化减少。自然杀伤细胞活性和干扰素γ产生与这些组蛋白残基的核乙酰化和磷酸化状态相关。这些发现证明了核表观遗传模式与伴随心理社会困扰的免疫失调之间的关联。
The molecular basis for psychosocial-distress mediated immune-dysregulation is not well understood. The purpose of this study was to determine whether peripheral blood mononuclear cell (PBMC) epigenetic pattern associates with this form of immune dysregulation. Women newly diagnosed with early stage breast cancer were enrolled into the study and psychosocial, immunological and epigenetic assessments were made at diagnosis and four months later, after completion of cancer treatment. At diagnosis women reported increased perceived stress, anxiety, and mood disturbance and the PBMC of these women exhibited reduced natural killer cell activity and reduced production of interferon gamma, which contrasted with results, obtained after completion of treatment. At the epigenetic level, a PBMC subset derived from women at diagnosis exhibited a distinct epigenetic pattern, with reduced nuclear acetylation of histone residues H4-K8 and H4-K12, as well as reduced phosphorylation of H3-S10, when compared to similar cells derived after the completion of treatment. Natural killer cell activity and interferon-gamma production were associated with nuclear acetylation and phosphorylation status of these histone residues. These findings demonstrate associations among nuclear epigenetic pattern and the immune dysregulation that accompanies psychosocial distress.
登录
查看更多内容
影响因子：
4.7
作者：
Chandramohan, Yalini;Droste, Susanne K.;Reul, Johannes M. H. M.
通讯作者：
Reul, Johannes M. H. M.
影响因子：
30.5
作者：
Arbibe, Laurence;Kim, Dong Wook;Sansonetti, Philippe J.
通讯作者：
Sansonetti, Philippe J.
影响因子：
32.4
作者：
DIGHE, AS;RICHARDS, E;SCHREIBER, RD
通讯作者：
SCHREIBER, RD
影响因子：
30.5
作者：
Avni, O;Lee, D;Rao, A
通讯作者：
Rao, A
影响因子：
4.8
作者：
Babichuk, CK;Duggan, BL;Bleackley, RC
通讯作者：
Bleackley, RC