Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure
Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure
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DOI：
10.1016/j.ijcard.2016.06.231
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发表时间：
2016-10-01
影响因子：
3.5
通讯作者：
Tsutsui, Hiroyuki
中科院分区：
文献类型：
--
作者：
Furihata, Takaaki;Kinugawa, Shintaro;Tsutsui, Hiroyuki
背景：据报道，心力衰竭（HF）患者的骨骼肌质量和力量下降，而心力衰竭与运动能力下降和不良临床结果相关。肌生长抑制素被称为肌肉生长的负调节剂，卵泡抑素作为肌生长抑制素拮抗剂，维持组织稳态。因此，我们测定了心力衰竭患者的血清肌生长抑制素水平以及它们是否与骨骼肌萎缩有关。 方法和结果：对 41 名连续心力衰竭患者（58 +/- 15 岁，纽约心脏协会 I-III 级）和 30 名年龄匹配的健康受试者（作为对照）（53 +/- 8 岁）进行了研究。心力衰竭患者的血清肌生长抑制素水平显着低于对照组（18.7 +/- 7.4 vs. 23.6 +/- 5.2 ng/mL，P < 0.001）。心力衰竭患者右大腿最厚部分的周长明显较小（468 +/- 72 vs. 559 +/- 37 mm，P = 0.001），下肢肌肉力量较低（129 +/- 55 vs. 219 +/- 52 N x m，P < 0.001）。 14 名心力衰竭患者 (34%) 出现肌肉萎缩。通过单变量分析，较高的年龄、较高的血清卵泡抑素和较低的血清肌生成抑制素与肌肉萎缩的存在显着相关。通过多变量分析，血清肌生长抑制素水平与肌肉萎缩独立相关（OR = 0.77，95% CI [0.58，0.93]，P = 0.02）。结论：心力衰竭患者血清肌生长抑制素水平显着降低，且与下肢肌肉萎缩相关，提示肌生长抑制素可能是心衰患者维持骨骼肌质量和强度的重要因素。 (C) 2016 Elsevier Ireland Ltd. 保留所有权利。
Background: It has been reported that skeletal muscle mass and strength are decreased in patients with heart failure (HF), and HF is associated with both reduced exercise capacity and adverse clinical outcomes. Myostatin has been known as a negative regulator of muscle growth, follistatin as the myostatin antagonist, maintaining tissue homeostasis. We thus determined serum myostatin levels in HF patients and whether they are associated with skeletal muscle wasting.Methods and results: Forty one consecutive HF patients (58 +/- 15 years old, New York Heart Association class I-III) and 30 age-matched healthy subjects as controls (53 +/- 8 years old) were studied. Serum myostatin levels were significantly lower in HF patients than controls (18.7 +/- 7.4 vs. 23.6 +/- 5.2 ng/mL, P < 0.001). Circumference of the thickest part of the right thigh was significantly small (468 +/- 72 vs. 559 +/- 37 mm, P = 0.001) and lower extremity muscular strength was lower in patients with HF (129 +/- 55 vs. 219 +/- 52 N x m, P < 0.001). Fourteen HF patients (34%) had muscle wasting. By univariate analysis, higher age, higher serum follistatin, and lower serum myostatin were significantly associated with the presence of muscle wasting. By multivariate analysis, serum myostatin levels were independently associated with muscle wasting (OR = 0.77, 95% CI [0.58, 0.93], P = 0.02).Conclusion: Serum myostatin levels were significantly decreased in HF patients and associated with lower extremity muscle wasting, suggesting that myostatin may be an important factor for maintaining skeletal muscle mass and strength in HF. (C) 2016 Elsevier Ireland Ltd. All rights reserved.