Kidney disease models: tools to identify mechanisms and potential therapeutic targets.
Kidney disease models: tools to identify mechanisms and potential therapeutic targets.
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DOI：
10.24272/j.issn.2095-8137.2017.055
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发表时间：
2018-03-18
影响因子：
4.9
通讯作者：
Lin WQ
中科院分区：
文献类型：
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作者：
Bao YW;Yuan Y;Chen JH;Lin WQ
急性肾损伤（阿基）和慢性肾脏疾病（CKD）是影响数百万人的全球公共卫生问题，近年来发病率迅速增加。由于肾衰竭的多种原因，已经开发了许多动物模型来促进我们对人类肾病的理解。在这些实验模型中，啮齿动物已被广泛用于使肾脏疾病的诱导和进展的机制的理解，以及确定潜在的治疗目标。本文就外科手术、药物或毒素诱导的阿基模型以及各种CKD模型（主要是转基因小鼠模型）作一综述。还探讨了最近和正在进行的临床试验的结果和来自动物模型的概念进展。
Acute kidney injury (AKI) and chronic kidney disease (CKD) are worldwide public health problems affecting millions of people and have rapidly increased in prevalence in recent years. Due to the multiple causes of renal failure, many animal models have been developed to advance our understanding of human nephropathy. Among these experimental models, rodents have been extensively used to enable mechanistic understanding of kidney disease induction and progression, as well as to identify potential targets for therapy. In this review, we discuss AKI models induced by surgical operation and drugs or toxins, as well as a variety of CKD models (mainly genetically modified mouse models). Results from recent and ongoing clinical trials and conceptual advances derived from animal models are also explored.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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