MicroRNAs (miRNAs) in neurodegenerative diseases
MicroRNAs (miRNAs) in neurodegenerative diseases
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DOI：
10.1111/j.1750-3639.2007.00120.x
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发表时间：
2008-01-01
期刊：
影响因子：
6.4
通讯作者：
Rajeev, Bernard W.
中科院分区：
文献类型：
--
作者：
Nelson, Peter T.;Wang, Wang-Xia;Rajeev, Bernard W.
衰老相关的神经退行性疾病（ND）是许多不同遗传和环境影响的结果。先前的研究表明，RNA在某些ND的不可阻挡的过程中发生了病理性改变。最近的证据表明，microRNAs（miRNAs）可能是神经退行性变的一个促成因素。miRNAs是脑内富集的小分子（类似于22个核苷酸）非编码RNA，参与mRNA的翻译调控。尽管miRNAs是在蠕虫发育的框架中发现的，但现在人们认识到miRNAs在许多哺乳动物脑相关的生化途径中发挥动态作用，包括神经可塑性和应激反应。关于miRNAs在神经退行性变背景下的研究正在迅速积累，本次综述的目标是为这些新数据提供视角，这些数据可能有助于这两个领域的专家。概述了miRNAs的正常功能，包括一些与人脑相关的新概念。最近发表的研究有关的作用，小RNA在ND-包括阿尔茨海默氏病，帕金森氏病和三重重复序列疾病的描述。最后，讨论了理论合成和未来可能的方向，探索miRNA和ND研究之间的联系。
Aging-related neurodegenerative diseases (NDs) are the culmination of many different genetic and environmental influences. Prior studies have shown that RNAs are pathologically altered during the inexorable course of some NDs. Recent evidence suggests that microRNAs (miRNAs) may be a contributing factor in neurodegeneration. miRNAs are brain-enriched, small (similar to 22 nucleotides) non-coding RNAs that participate in mRNA translational regulation. Although discovered in the framework of worm development, miRNAs are now appreciated to play a dynamic role in many mammalian brain-related biochemical pathways, including neuroplasticity and stress responses. Research about miRNAs in the context of neurodegeneration is accumulating rapidly, and the goal of this review is to provide perspective for these new data that may be helpful to specialists in either field. An overview is provided about the normal functions for miRNAs, including some of the newer concepts related to the human brain. Recently published studies pertaining to the roles of miRNAs in NDs-including Alzheimer's disease, Parkinson's disease and triplet repeat disorders-are described. Finally, a discussion is included with theoretical syntheses and possible future directions in exploring the nexus between miRNA and ND research.