Photodynamic Activity of Liposomal Photosensitizers via Energy Transfer from Antenna Molecules to [60]Fullerene
Photodynamic Activity of Liposomal Photosensitizers via Energy Transfer from Antenna Molecules to [60]Fullerene
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DOI：
10.1021/ml100021x
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发表时间：
2010-06-01
影响因子：
4.2
通讯作者：
Takeya, Tatsuo
中科院分区：
文献类型：
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作者：
Ikeda, Atsushi;Akiyama, Motofusa;Takeya, Tatsuo
光动力疗法(PDT)是一种新兴的治疗肿瘤疾病的方法，在过去几年中受到了越来越多的关注。在这项研究中，我们通过将[60]富勒烯(C-60)致密到脂膜双层中，作为捕光“天线”分子，构建了用于PDT的脂质体光敏剂(PS)。脂质体PS通过将光能从光活化的天线分子转移到C-60，提高了对人类癌细胞的光动力活性。
Photodynamic therapy (PDT) is an emerging approach for the treatment of tumor diseases that has received growing interest in the past few years. In this study, we constructed liposomal photosensitizers (PS) for PDT by shoehorning as light-harvesting "antenna" molecules and dense [60]fullerene (C-60) into lipid membrane bilayers. The liposomal PS showed improved photodynamic activity toward human cancer cells via the photoenergy transfer from photoactivated antenna molecules to C-60.