NOVEL POLYCATIONIC BIOCIDES - SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF POLYMERIC PHOSPHONIUM SALTS
NOVEL POLYCATIONIC BIOCIDES - SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF POLYMERIC PHOSPHONIUM SALTS
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DOI：
10.1002/pola.1993.080310205
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发表时间：
1993-02-01
影响因子：
--
通讯作者：
ENDO, T
中科院分区：
文献类型：
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作者：
KANAZAWA, A;IKEDA, T;ENDO, T
制备了各种聚合物膦盐和相应的低分子模型化合物，并在无菌蒸馏水中用活细胞计数法研究了它们对金黄色葡萄球菌和大肠杆菌的抑菌活性。发现聚合物的抗菌活性高于相应的模型化合物，尤其是对金黄色葡萄球菌的抗菌活性。此外，除阳离子部分外，聚合物季铵盐的活性比相同结构的聚合物季铵盐高2个数量级。所研究的烷基链最长的化合物(辛基)表现出特别高的活性，这可能归因于化合物的疏水性增加对杀灭活性的贡献。
Various polymeric phosphonium salts and the corresponding low-molecular-weight model compounds were prepared and their antibacterial activities against Staphylococcus aureus and Escherichia coli were explored by the viable cell counting method in sterile distilled water. Antibacterial activity of the polymers was found to be higher than that of the corresponding model compounds, particularly against S. aureus. Furthermore, the polymeric phosphonium salt exhibited a higher activity by 2 orders of magnitude than the polymeric quaternary ammonium salt with the same structure except the cationic part. Compounds with the longest alkyl chain (octyl) studied were found to exhibit particularly high activity, and this finding may be ascribed to the contribution of the increased hydrophobicity of the compounds to the cidal activity.