The advanced adenoma as the primary target of screening.
The advanced adenoma as the primary target of screening.
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DOI：
10.1016/s1052-5157(03)00053-9
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发表时间：
2002-01-01
影响因子：
--
通讯作者：
Zauber, Ann G
中科院分区：
文献类型：
--
作者：
Winawer, Sidney J;Zauber, Ann G
晚期腺瘤是良性和恶性状态的桥梁，可能是目前和未来结直肠癌风险的最有效的肿瘤替代标志物。我们将晚期腺瘤定义为具有明显绒毛特征（>25%）、大小为1.0 cm或以上、高度异型增生或早期浸润性癌的腺瘤。预防研究应该证明在减少晚期腺瘤的数量方面具有很高的疗效。我们应该在新的筛查技术、营养干预和化学预防剂的评估中使用晚期腺瘤，因为晚期腺瘤是筛查效果的更理想目标，而不是更罕见但危及生命的癌症阶段或更常见但早期、不太重要的小腺瘤阶段。
The advanced adenoma bridges benign and malignant states and may be the most valid neoplastic surrogate marker for present and future colorectal cancer risk. We define the advanced adenoma as an adenoma with significant villous features (>25%), size of 1.0 cm or more, high-grade dysplasia, or early invasive cancer. Prevention studies should demonstrate a high efficacy in reducing the number of advanced adenomas. We should use the advanced adenoma in the evaluation of new screening technology, nutritional interventions, and chemoprevention agents because the advanced adenoma is a more desirable target for screening efficacy than is the more uncommon but life-threatening cancer stage or the more common but early, less significant small adenoma stage.