Rausuquinone, a non-glycosylated pluramycin-class antibiotic from Rhodococcus
Rausuquinone, a non-glycosylated pluramycin-class antibiotic from Rhodococcus
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DOI：
10.1038/s41429-021-00489-0
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发表时间：
2021-11-30
影响因子：
3.3
通讯作者：
Igarashi, Yasuhiro
中科院分区：
文献类型：
--
作者：
Harunari, Enjuro;Bando, Maho;Igarashi, Yasuhiro
从深海水源红球菌RD 015140的培养物提取物中分离到一种新的普雷霉素类聚酮化合物rausuquinone（1）及其已知的同源物海霉素（2）。化合物1具有γ-吡喃酮稠合的蒽醌核和3-丁烯-1，2-二醇侧链。通过对1D和2D NMR光谱数据的广泛分析确定了1的结构。化合物1对革兰氏阳性菌具有抗菌活性。这是首次从红球菌属中发现芳香聚酮化合物。
A new pluramycin-class polyketide, rausuquinone (1), and its known congener hydramycin (2) were isolated from the culture extract of the deep-sea water-derived Rhodococcus sp. RD015140. Compound 1 possesses a gamma-pyrone-fused anthraquinone core with a 3-butene-1,2-diol side chain. Structures of 1 was determined by extensive analysis of 1D and 2D NMR spectroscopic data. Compound 1 showed antimicrobial activity against Gram-positive bacteria. This is the first discovery of aromatic polyketides from the genus Rhodococcus.