THE HISTORY OF ALZHEIMERS-DISEASE - 3 DEBATES
THE HISTORY OF ALZHEIMERS-DISEASE - 3 DEBATES
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DOI：
10.1093/jhmas/42.3.327
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发表时间：
1987-07-01
影响因子：
0.5
通讯作者：
BEACH, TG
中科院分区：
文献类型：
--
作者：
BEACH, TG
LZHEIMER病、早老性和老年性痴呆、脑动脉硬化、”动脉硬化”和”衰老”是本世纪用来描述老年人记忆力和智力丧失的一些医学和非专业术语。[1]从这个混乱的过去，出现了某些有用的临床和病理定义。在临床上，当患者的智力普遍丧失，干扰了社会或职业功能时，就被认为处于痴呆状态。记忆力、判断力和抽象思维受损，人格也会发生变化。2.痴呆症的病因可能是原发性的，即源于大脑的疾病，也可能是继发性的，即系统性的过程或通过非神经颅内容物的延伸而影响大脑的过程。许多次要原因是可以诊断和治疗的。3大多数老年痴呆症是原发性痴呆症，而迄今为止，原发性痴呆症的最大病因是阿尔茨海默病，也称为阿尔茨海默型老年痴呆症。这种情况大约占65岁以上老年痴呆症患者的一半。4
LZHEIMER'S disease, presenile and senile dementia, cerebral arteriosclerosis," hardening of the arteries" and" senility" are some of the medical and lay terms used during this century to describe memory and intellectual losses in the aged. 1 From this confusing past certain useful clinical and pathological definitions have emerged. Clinically the patient is said to be in a state of dementia when there is a general loss of intellectual ability which interferes with social or occupational functioning. Memory, judgment, and abstract thought are impaired, and changes in personality also occur. 2 The causes of dementia may be primary, due to diseases originating in the brain, or secondary, due to processes which are systemic in nature or which affect the brain by extension from the non-neural cranial contents. Many secondary causes are diagnosable and treatable. 3 Most dementia in the elderly is primary dementia, and by far the largest cause of primary dementia is Alzheimer's disease, also known as senile dementia of the Alzheimer type. This condition accounts for roughly half of all dementia in people over age sixty-five. 4