Intrinsic amygdala-cortical functional connectivity predicts social network size in humans.
Intrinsic amygdala-cortical functional connectivity predicts social network size in humans.
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DOI：
10.1523/jneurosci.1599-12.2012
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发表时间：
2012-10-17
期刊：
影响因子：
--
通讯作者：
Dickerson BC
中科院分区：
文献类型：
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作者：
Bickart KC;Hollenbeck MC;Barrett LF;Dickerson BC
利用来自两个独立健康成年人样本的静息态功能 MRI 数据，我们将杏仁核的内在连接性解析为三个部分不同的大规模网络，这些网络与已知的啮齿类动物和猴子杏仁核连接性的解剖结构非常相似。此外，在第三个独立样本中，我们发现培养和维持更大、更复杂的社交网络的人不仅有更大的杏仁核体积，而且在其中两个网络中杏仁核具有更强的内在连接性，一个假定促进感知能力，一个促进亲和行为。我们的研究结果在解剖学上是特定于杏仁核回路的，因为社交网络大小和复杂性的个体差异不能用两个网络内节点之间的内在连接强度来解释，这两个网络通常不涉及杏仁核（即心智化和镜像网络），并且在行为上是特定的，因为杏仁核连接性与其他社交性自我报告测量不相关。
Using resting-state functional MRI data from two independent samples of healthy adults, we parsed the amygdala’s intrinsic connectivity into three partially-distinct large-scale networks that strongly resemble the known anatomical organization of amygdala connectivity in rodents and monkeys. Moreover, in a third independent sample, we discovered that people who fostered and maintained larger and more complex social networks not only had larger amygdala volumes, but also amygdalae with stronger intrinsic connectivity within two of these networks, one putatively subserving perceptual abilities and one subserving affiliative behaviors. Our findings were anatomically specific to amygdalar circuitry in that individual differences in social network size and complexity could not be explained by the strength of intrinsic connectivity between nodes within two networks that do not typically involve the amygdala (i.e., the mentalizing and mirror networks), and were behaviorally specific in that amygdala connectivity did not correlate with other self-report measures of sociality.