MILK IS A USEFUL TEST MEAL FOR MEASUREMENT OF SMALL-BOWEL TRANSIT-TIME
MILK IS A USEFUL TEST MEAL FOR MEASUREMENT OF SMALL-BOWEL TRANSIT-TIME
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DOI：
10.1007/bf02349276
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发表时间：
1994-12-01
影响因子：
6.3
通讯作者：
TODA, Y
中科院分区：
文献类型：
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作者：
KONDO, T;LIU, F;TODA, Y
为了改进和标准化小肠通过时间的测量，采用牛奶代替常规乳果糖餐作为试验餐。 虽然92%的受试者缺乏乳糖酶，但只有2%的受试者对牛奶不耐受，13%的受试者对乳糖不耐受。 母乳小肠通过时间（牛奶呼气氢试验）为113 +/- 9分钟（平均值+/- SE，n = 20）;从平均值+/-2SD计算的正常范围为31-195分钟。牛奶氢呼气试验的变异系数为13 +/-4%（n = 6），而在乳果糖氢呼气试验中，为39 ± 16%（n = 10）。 非氢生产者的频率，不适的发生，和再现性更好，虽然不显着，在牛奶氢呼吸试验比乳果糖。 由于乳糖酶缺乏受试者肠道中的乳糖酶活性是可变的，因此乳汁的小肠通过时间可能因受试者而异。 但是，乳氢呼气试验的个体重现性良好。 它可能是有用的药理学实验，使用配对比较，筛选试验，或跟踪的疾病，其中小肠通过时间受到影响。
To improve and standardize the measurement of small bowel transit time, milk was employed for the test meal instead of the conventional lactulose meal. Although 92% of the subjects were lactase deficient, only 2% were milk intolerant and 13% were lactose intolerant. Small bowel transit time with milk (milk breath hydrogen test) was 113 +/- 9 min (mean +/- SE, n = 20); the normal range calculated from the mean +/- 2 SD was 31-195 min. The coefficient of variation in the milk hydrogen breath test was 13 +/- 4% (n = 6), whereas in the lactulose hydrogen breath test, it was 39 +/- 16% (n = 10). The frequency of non-hydrogen producers, the occurrence of discomfort, and the reproducibility were better, though not significantly so, in the milk hydrogen breath test than in the lactulose. Since lactase activity in the intestine is variable in lactase-deficient subjects, small bowel transit times for milk may change from subject to subject. However, individual reproducibility of the milk hydrogen breath test is good. It could be useful for pharmacological experiments using paired comparison, for screening tests, or for the follow up of diseases in which small bowel transit time is affected.