A 128 × 128 CMOS bio-sensor array for extracellular recording of neural activity
A 128 × 128 CMOS bio-sensor array for extracellular recording of neural activity
复制标题
用于神经活动细胞外记录的 128 × 128 CMOS 生物传感器阵列
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
R. Thewes
中科院分区：
文献类型：
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作者：
B. Eversmann;M. Jenkner;F. Hofmann;C. Paulus;R. Brederlow;B. Holzapfl;P. Fromherz;M. Merz;Markus Brenner;M. Schreiter;R. Gabl;K. Plehnert;M. Steinhauser;G. Eckstein;D. Schmitt;R. Thewes
传感器阵列是神经科学领域中用于非侵入性记录生物网络（诸如分离的神经元或神经组织）的活动的关键工具。一个高密度的传感器阵列互补金属氧化物半导体芯片，提出了16 K像素，每秒2千帧的帧速率，和7.8米-7.8米的间距神经活动的成像。相关的电路和系统的问题，以及工艺方面进行了讨论。使用具有电流模式信号表示的失配消除校准电路。从第一个生物实验的结果，这证明了芯片的全部功能。
Sensor arrays are a key tool in the field of neuroscience for noninvasive recording of the activity of biological networks, such as dissociated neurons or neural tissue. A high-density sensor array complementary metal–oxide–semiconductor chip is presented with 16 K pixels, a frame rate of 2 kiloframes per second, and a pitch of 7.8 m 7.8 m for imaging of neural activity. The related circuit and system issues as well as process aspects are discussed. A mismatch-canceling calibration circuitry with current mode signal representation is used. Results from first biological experiments are presented, which prove full functionality of the chip.