Imaging of somatotopic representation of sensory cortex with intrinsic optical signals as guides for brain tumor surgery
Imaging of somatotopic representation of sensory cortex with intrinsic optical signals as guides for brain tumor surgery
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DOI：
10.3171/jns.2005.103.3.0414
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发表时间：
2005-09-01
影响因子：
4.1
通讯作者：
Ohno, K
中科院分区：
文献类型：
--
作者：
Nariai, T;Sato, K;Ohno, K
物体。在脑肿瘤手术中记录到对体感刺激作出反应的本征光学信号。在本研究中，作者报告了这项技术的使用作为术中安全切除邻近或位于感觉运动皮质内的肿瘤的指导。在14例邻近或位于感觉运动皮质内的肿瘤患者中，用Xe白光照射脑表面，并通过带通滤光器(605 Nm)成像，记录了对体感刺激作出反应的本征光信号。将结果与所有14名患者的术中感觉诱发电位记录进行比较，并与选定患者的无创标测方法(如脑磁图和正电子发射断层扫描)进行比较。除两名患者外，所有患者的体感光信号都记录在初级感觉皮质上。在感觉条上的不同位置记录刺激第一、五指和三叉神经三支所产生的光信号。这一体视学信息有助于确定位于感觉运动皮质的胶质瘤患者的切除边界。本征信号的光学成像是描述人类初级感觉皮层体视呈现的一种有用的技术，具有较高的空间分辨率。此外，它还可以作为术中监测工具，提高邻近感觉运动皮质或位于感觉运动皮质内的脑肿瘤切除的安全性和准确性。
Object. Intrinsic optical signals in response to somatosensory stimuli were intraoperatively recorded during brain tumor surgery. In the present study, the authors report on the use of this technique as an intraoperative guide for the safe resection of tumors adjacent to or within the sensorimotor cortex.Methods. In 14 patients with tumors adjacent to or within the sensorimotor cortex, intrinsic optical signals in response to somatosensory stimuli were recorded by illuminating the brain surface with Xe white light and imaging the reflected light passing through a bandpass filter (605 nm). Results were compared with intraoperative recordings of sensory evoked potentials in all 14 patients and with noninvasive mapping modalities such as magnetoencephalography and positron emission tomography in selected patients. In all but two patients, the somatosensory optical signals were recorded on the primary sensory cortex. Optical signals elicited by stimulation of the first and fifth digits and the three branches of the trigeminal nerve were recorded at different locations on the sensory strip. This somatotopic information was useful in determining the resection border in patients with glioma located in the sensorimotor cortex.Conclusions. Optical imaging of intrinsic signals is a useful technique with superior spatial resolution for delineating the somatotopic representation of human primary sensory cortex. Furthermore, it can be used as an intraoperative monitoring tool to improve the safety and accuracy of resections of brain tumors adjacent to or within the sensorimotor cortex.