The utility of drug testing in epidemiological research: results from a general population survey
The utility of drug testing in epidemiological research: results from a general population survey
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DOI：
10.1111/j.1360-0443.2003.00632.x
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发表时间：
2004-02-01
期刊：
影响因子：
6
通讯作者：
Spiehler, V
中科院分区：
文献类型：
--
作者：
Fendrich, M;Johnson, TP;Spiehler, V
目的：评估生物测试的效用在一般人群调查估计患病率和评估自我报告的数据quality.Design音频计算机辅助访谈管理的主题从2001年6月至2002年1月。访谈结束后，立即要求受试者参加头发，口腔液和尿液testing. Set受试者来自随机选择的家庭在城市的芝加哥使用多阶段抽样方法。访谈进行了受试者的homes.Participants数据代表627随机选择的成年人参与者，年龄18-40 years.Measurements患病率，Kappa，条件Kappa，敏感性，特异性，漏报，“混合模型”和logistic regression.Findings更高的大麻使用率产生的调查报告比药物测试。毒品检测得出的可卡因和海洛因近期使用流行率高于调查报告。所有这三种物质的近期吸毒情况都明显报告不足。对可卡因和海洛因的敏感性特别低。种族是有关的报告不足，与非洲裔美国人不太可能报告大麻的使用，尽管一个积极的测试结果。结论药物测试的调查的效用取决于检查的物质类型以及测试的类型。多个测试比单个测试更有用。药物检测有助于查明调查中少报的程度和来源，并为根据自我报告调整流行率估计数提供依据。
Aims To assess the utility of biological testing in a general population survey for estimating prevalence and evaluating self-report data quality.Design An audio computer-assisted interview was administered to subjects from June 2001 to January 2002. Immediately following the interview, subjects were requested to participate in hair, oral fluid and urine testing.Setting Subjects were from randomly selected households in the City of Chicago using multi-stage sampling methods. Interviews were conducted in subjects' homes.Participants The data represent 627 randomly selected adult participants, ages 18-40 years.Measurements Prevalance, kappa, conditioned kappa, sensitivity, specificity, under-reporting, 'mixed model' and logistic regression.Findings Higher rates of marijuana use were generated from survey reports than from drug testing. Drug testing generated higher prevalence rates than survey reports for recent use of cocaine and heroin. Under-reporting of recent drug use was apparent for all three substances. Sensitivity was particularly low for cocaine and heroin. Race was related to under-reporting, with African Americans less likely to report marijuana use despite a positive test result.Conclusions The utility of drug testing for surveys depends on the type of substance examined as well as on the type of test employed. Multiple tests have more utility than a single test. Drug testing is useful for identifying the levels and sources of under-reporting in a survey and provides a basis for adjusting prevalence estimates based on self-reports.