Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology
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DOI：
10.1016/j.molmed.2003.11.002
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发表时间：
2004-01-01
影响因子：
13.6
通讯作者：
Doerr, HW
中科院分区：
文献类型：
--
作者：
Cinati, J;Scholz, M;Doerr, HW
最近，术语肿瘤调节已被提出来表达人巨细胞病毒（HCMV）改变肿瘤细胞生物学的能力，这是一种独立于转化的现象。由于过去的研究未能表明HCMV可以转化正常的人类细胞，因此HCMV一直没有被认为是致癌的肿瘤病毒。然而，最近的研究表明，在结肠癌、恶性神经胶质瘤、前列腺上皮内瘤和癌等恶性肿瘤的肿瘤细胞中，HCMV的频率很高。来自HCMV感染的肿瘤细胞系的实验数据突出了HCMV的肿瘤调节潜力，并提供了与宿主细胞的异常信号传导途径和转录因子和/或肿瘤抑制功能相关的病理机制的重要见解。
Recently, the term oncomodulation has been proposed to express the ability of human cytomegalovirus (HCMV) to modify tumor cell biology, a phenomenon that is independent from transformation. Because past studies have failed to show that HCMV can transform normal human cells, HCMV has not been regarded as an oncogenic tumor virus. However, recent investigations have revealed a high frequency of HCMV in tumor cells of malignancies such as colon cancer, malignant glioma, prostatic intraepithelial neoplasia, and carcinoma. Data from experiments with HCMV-infected tumor cell lines have highlighted the oncomodulatory potential of HCMV and provided important insights into the patho-mechanisms associated with aberrant signaling pathways and transcription factor and/or tumor suppressor function of the host cell.