Attention differentially modulates the amplitude of resonance frequencies in the visual cortex
Attention differentially modulates the amplitude of resonance frequencies in the visual cortex
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DOI：
10.1016/j.neuroimage.2019.116146
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发表时间：
2019-12-01
期刊：
影响因子：
5.7
通讯作者：
VanRullen, Rufin
中科院分区：
文献类型：
--
作者：
Gulbinaite, Rasa;Roozendaal, Diane H. M.;VanRullen, Rufin
有节奏的视觉刺激（闪烁）在刺激的频率下引起有节奏的大脑反应，注意力通常会增强这些振荡的大脑反应（稳态视觉诱发电位，SSVEP）。尽管已经针对高达100 Hz的闪烁频率测试了SSVEP响应[Herrmann，2001]，但仅报告了较低频率（高达30 Hz）下注意力对SSVEP振幅的影响，没有在宽的精细采样频率范围内进行系统比较。注意力是否在较高的闪烁频率（伽马波段，30-80 Hz）下调制SSVEP振幅，注意力调制在不同频率下是否恒定？通过使用多变量时空源分离方法从宽带EEG信号中分离SSVEP响应，我们证明了在α和γ频带中的闪烁引起最强和最大相位稳定的脑响应（共振），注意力的影响是相反的：γ为正，α为负。发现受试者特定的伽马共振频率和积极的注意力调制的伽马波段SSVEP点闪烁作为一种非侵入性的工具，用于研究视觉伽马波段节律刺激和内源性伽马振荡之间的相互作用对感知和注意力的因果关系的未开发的潜力。
Rhythmic visual stimuli (flicker) elicit rhythmic brain responses at the frequency of the stimulus, and attention generally enhances these oscillatory brain responses (steady state visual evoked potentials, SSVEPs). Although SSVEP responses have been tested for flicker frequencies up to 100 Hz [Herrmann, 2001], effects of attention on SSVEP amplitude have only been reported for lower frequencies (up to similar to 30 Hz), with no systematic comparison across a wide, finely sampled frequency range. Does attention modulate SSVEP amplitude at higher flicker frequencies (gamma band, 30-80 Hz), and is attentional modulation constant across frequencies? By isolating SSVEP responses from the broadband EEG signal using a multivariate spatiotemporal source separation method, we demonstrate that flicker in the alpha and gamma bands elicit strongest and maximally phase stable brain responses (resonance), on which the effect of attention is opposite: positive for gamma and negative for alpha. Finding subject-specific gamma resonance frequency and a positive attentional modulation of gamma-band SSVEPs points to the untapped potential of flicker as a non-invasive tool for studying the causal effects of interactions between visual gamma-band rhythmic stimuli and endogenous gamma oscillations on perception and attention.