The primary cilium as a cellular receiver: organizing ciliary GPCR signaling.
The primary cilium as a cellular receiver: organizing ciliary GPCR signaling.
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DOI：
10.1016/j.ceb.2016.02.008
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发表时间：
2016-04
影响因子：
7.5
通讯作者：
Jackson PK
中科院分区：
文献类型：
--
作者：
Hilgendorf KI;Johnson CT;Jackson PK
初级纤毛是天线样的细胞突起，介导感觉和神经内分泌信号。它在组织结构中的定位和越来越多的纤毛定位受体，特别是g蛋白偶联受体，决定了许多关键的生理机能，这些生理机能在人类纤毛病中被破坏。在这里，我们讨论了最近在鉴定和表征纤毛信号成分和途径的进展。最近的研究强调了初级纤毛的独特信号环境，我们刚刚开始了解这种设计如何允许高度放大和调节信号。
The primary cilium is an antenna-like cellular protrusion mediating sensory and neuroendocrine signaling. Its localization within tissue architecture and a growing list of cilia-localized receptors, in particular G-protein-coupled receptors, determine a host of critical physiologies, which are disrupted in human ciliopathies. Here, we discuss recent advances in the identification and characterization of ciliary signaling components and pathways. Recent studies have highlighted the unique signaling environment of the primary cilium and we are just beginning to understand how this design allows for highly amplified and regulated signaling.