Emerging views on the distinct but related roles of the main and accessory olfactory systems in responsiveness to chemosensory signals in mice
Emerging views on the distinct but related roles of the main and accessory olfactory systems in responsiveness to chemosensory signals in mice
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DOI：
10.1016/j.yhbeh.2004.02.009
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发表时间：
2004-09-01
影响因子：
3.5
通讯作者：
Lin, WH
中科院分区：
文献类型：
--
作者：
Restrepo, D;Arellano, J;Lin, WH
在啮齿类动物中，鼻腔包含两个独立的化学感觉上皮：位于鼻腔后背侧的主嗅觉上皮和位于鼻腔腹底前部的囊状鼻/副嗅觉上皮。主嗅觉系统和辅助嗅觉系统都在检测生物相关气味方面发挥作用。副嗅觉系统涉及对信息素的反应，而主嗅觉系统被认为是一个能够检测挥发性气味剂分子结构细微差异的一般分子分析仪。然而，这两个系统在检测生物学相关化学信号方面的作用似乎部分重叠。因此，虽然很明显，副嗅觉系统对假定的信息素有反应，但主嗅觉系统也可以对某些信息素有反应。相反，虽然主要的嗅觉系统可以通过气味介导对基因组成差异的识别，但犁鼻器官（VNO）似乎也参与了对基因不同个体之间化学感觉差异的识别。我们对文献回顾的最显著特征是，没有一般规则允许将辅助嗅觉系统分类为信息素探测器和主嗅觉系统分类为一般气味探测器。相反，每种行为都必须在特定的行为背景下考虑，以确定这两种化学感觉系统的作用。在每种情况下，一个系统或另一个系统（或两者）参与特定的行为或激素反应。(C) 2004爱思唯尔公司版权所有。
In rodents, the nasal cavity contains two separate chemosensory epithelia, the main olfactory epithelium, located in the posterior dorsal aspect of the nasal cavity, and the vomeronasal/accessory olfactory epithelium, located in a capsule in the anterior aspect of the ventral floor of the nasal cavity. Both the main and accessory olfactory systems play a role in detection of biologically relevant odors. The accessory olfactory system has been implicated in response to pheromones, while the main olfactory system is thought to be a general molecular analyzer capable of detecting subtle differences in molecular structure of volatile odorants. However, the role of the two systems in detection of biologically relevant chemical signals appears to be partially overlapping. Thus, while it is clear that the accessory olfactory system is responsive to putative pheromones, the main olfactory system can also respond to some pheromones. Conversely, while the main olfactory system can mediate recognition of differences in genetic makeup by smell, the vomeronasal organ (VNO) also appears to participate in recognition of chemosensory differences between genetically distinct individuals. The most salient feature of our review of the literature is that there are no general rules that allow classification of the accessory olfactory system as a pheromone detector and the main olfactory system as a detector of general odorants. Instead, each behavior must be considered within a specific behavioral context to determine the role of these two chemosensory systems. In each case, one system or the other (or both) participates in a specific behavioral or hormonal response. (C) 2004 Elsevier Inc. All rights reserved.