Anti-NMDA Receptor Encephalitis in Psychiatry.
Anti-NMDA Receptor Encephalitis in Psychiatry.
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DOI：
10.2174/157340011797183184
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发表时间：
2011
影响因子：
--
通讯作者：
Dalmau J
中科院分区：
文献类型：
--
作者：
Kayser MS;Dalmau J
抗NMDA受体脑炎是一种自身免疫性疾病，其中抗体攻击中枢神经元突触处的NMDA（N-甲基-D-天冬氨酸）型谷氨酸受体。症状包括一组高度特征性的神经功能缺损，但也有突出的精神病表现，往往使心理健康专业人员进入护理过程。疾病的不同阶段越来越受到重视，包括疾病早期的一系列精神病症状，随后是更严重的意识波动，神经系统受累，最终是长期的认知和行为缺陷。年轻女性最常见的影响和卵巢畸胎瘤有时与综合征。患者对免疫疗法反应良好，但精神症状可能难以控制。我们提供了一个最新的审查，这种疾病，并强调精神病学在诊断，精神病学和治疗的作用。
Anti-NMDA receptor encephalitis is an autoimmune disorder in which antibodies attack NMDA (N-methyl-D-aspartate)-type glutamate receptors at central neuronal synapses. Symptoms include a highly characteristic set of neurologic deficits, but also prominent psychiatric manifestations that often bring mental health professionals into the course of care. Distinct phases of illness have become increasingly appreciated, and include a range of psychotic symptoms early in the course of the disease followed by more severe fluctuations in consciousness with neurologic involvement, and ultimately protracted cognitive and behavioral deficits. Young women are most commonly impacted and an ovarian teratoma is sometimes associated with the syndrome. Patients respond well to immunotherapy, but psychiatric symptoms can be challenging to manage. We provide an up to date review of this disorder and highlight the role of psychiatry in diagnosis, symptomatology, and treatment.