A simple oxazolidine linker for solid-phase synthesis of peptide aldehydes
A simple oxazolidine linker for solid-phase synthesis of peptide aldehydes
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DOI：
10.1016/j.bmcl.2011.11.081
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发表时间：
2012-01-15
影响因子：
2.7
通讯作者：
Xu, HongYan
中科院分区：
文献类型：
--
作者：
Kang, Wu;Wang, Weiguo;Xu, HongYan
一种非常简单和廉价的连接剂用于肽醛的固相合成。保护氨基酸醛固定在2-Cl（trt）树脂上，通过二乙醇胺形成恶唑烷。经过经典的Fmoc SPPS后，用AcOH/DCM/H2O（8:1:1）处理树脂，可获得高产率和高纯度的肽醛。(C) 2011 Elsevier Ltd.版权所有。
A very simple and cheap linker has been used for solid-phase synthesis of peptide aldehydes. Protected amino acid aldehydes are immobilized on 2-Cl(trt) resin as oxazolidine formation via diethanolamine. After classical Fmoc SPPS, treatment of the resin with AcOH/DCM/H2O (8:1:1) affords peptide aldehydes in high yield and purity. (C) 2011 Elsevier Ltd. All rights reserved.