STROKE RELATED TO CEREBRAL AMYLOID ANGIOPATHY - THE SIGNIFICANCE OF SYSTEMIC VASCULAR-DISEASE
STROKE RELATED TO CEREBRAL AMYLOID ANGIOPATHY - THE SIGNIFICANCE OF SYSTEMIC VASCULAR-DISEASE
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DOI：
10.1007/bf00314454
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发表时间：
1989-01-01
影响因子：
6
通讯作者：
VINTERS, HV
中科院分区：
文献类型：
--
作者：
FERREIRO, JA;ANSBACHER, LE;VINTERS, HV
本文报告25例脑淀粉样血管病（CAA）合并阿尔茨海默病或阿尔茨海默型老年性痴呆（AD/SDAT）的尸检资料。7例患者发生了具有临床意义的脑梗死或脑梗死或两者兼有。高血压和非高血压患者的梗死或脑梗死发生率无统计学显著差异。在AD/SDAT背景下，高血压似乎不是CAA相关脑梗死或出血的额外危险因素。一半以上的CAA和明显的缺血性和/或出血性脑病变患者显示Willis环动脉粥样硬化，有时在严重的播散性动脉粥样硬化疾病的背景下。
A retrospective postmortem analysis of 25 cases of cerebral amyloid angiopathy (CAA) in the setting of Alzheimer''s disease or senile dementia of the Alzheimer type (AD/SDAT) is reported. Seven patients experienced clinically significant cerebral infarcts or hemorrhages or both. There was not statistically significant difference in the incidence of infarcts or hemorrhages in hypertensive and nonhypertensive patients. Hypertension does not appear to be an additional risk factor in the causation of cerebral infarct or hemorrhage associated with CAA in the setting of AD/SDAT. Just over half of patients wiht CAA and significant ischemic and/or hemorrhagic brain lesions showed atherosclerosis of the circle of Willis, sometimes in the context of severe disseminated atheromatous disease.