NOMENCLATURE OF PERICYTES - INTRAMURAL AND EXTRAMURAL
NOMENCLATURE OF PERICYTES - INTRAMURAL AND EXTRAMURAL
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DOI：
10.1136/bjo.50.3.119
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发表时间：
1966-01-01
影响因子：
4.1
通讯作者：
DEOLIVEI.F
中科院分区：
文献类型：
--
作者：
ASHTON, N;DEOLIVEI.F
Kuwabara和Cogan（1960）最近介绍的消化技术揭示了视网膜血管的细胞结构，引起了广泛的兴趣和猜测，特别是关于嵌在视网膜毛细血管壁中的细胞的性质和功能。Cogan和他的同事起初认为这些是血管周围神经胶质细胞的细胞核，但后来得出结论，它们是局限于视网膜循环的特殊细胞（Kuwabara和Cogan，1963），其中它们可能与毛细血管血流的控制有关，并且在糖尿病视网膜病变中被选择性损伤，在其发病机制中具有重要意义（Cogan，Toussaint和Kuwabara，1961）。相信这些细胞是以前没有描述过的实体，他们给它们起了一个特殊的名字”壁细胞”，这个术语已经在文献中被确立为视网膜毛细血管的一个特定组成部分。从我们自己的观察和文献回顾中，很明显这种细胞实际上不是视网膜所特有的，但与在整个血管系统中发现的一种细胞相对应，并且长期以来被分类为混淆术语”周细胞”。现在，不仅在眼科工作中，而且在一般的血管研究中，澄清命名并选择一个准确描述这些细胞的术语已经变得至关重要。
THE cellular structure of the retinal vessels as revealed by the digest technique recently introduced by Kuwabara and Cogan (1960) has aroused widespread interest and speculation, especially concerning the nature and function of the cells to be found embedded in the walls of the retinal capillaries. Cogan and his colleagues at first thought that these were the nuclei of perivascular glia, but later concluded that they were special cells confined to the retinal circulation (Kuwabara and Cogan, 1963), wherein they were probably concerned in the control of capillary blood flow, and, being selectively injured in diabetic retinopathy, were of significance in its pathogenesis (Cogan, Toussaint, and Kuwabara, 1961). Believing that these cells were an entity not previously described they gave them the special name of" mural cells", a term which is already becoming establishedin the literature as a specific component of the retinal capillaries.From our own observations and from a review of the literature, it has since become clear that this cell is not in fact unique to the retina, but corresponds to one type of cell found throughout the vascular system, and long classified under the confusing term of" pericyte". It has now become essential, not only in ophthalmological work, but also in general vascular studies, to clarify the nomenclature and select a term that accurately describes these cells wherever they may be found.