COMPARISON OF MEASURED TORSO POTENTIALS WITH THOSE SIMULATED FROM EPICARDIAL POTENTIALS FOR VENTRICULAR DEPOLARIZATION AND REPOLARIZATION IN INTACT DOG
COMPARISON OF MEASURED TORSO POTENTIALS WITH THOSE SIMULATED FROM EPICARDIAL POTENTIALS FOR VENTRICULAR DEPOLARIZATION AND REPOLARIZATION IN INTACT DOG
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DOI：
10.1161/01.res.41.5.660
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发表时间：
1977-01-01
影响因子：
20.1
通讯作者：
SPACH, MS
中科院分区：
文献类型：
--
作者：
RAMSEY, M;BARR, RC;SPACH, MS
本研究的目的是模拟体表电位分布，毫秒毫秒，直接从心外膜的完整的狗，并检查所得的模拟比较，它与测量的体表电位分布测量的电位分布。包括在这个目标是一个模拟，不仅涉及到去极化，与以前的模拟几乎完全关注的心脏活动的那些阶段，而且重叠的去极化和复极的时间，以及时间在复极单独。为了实现这一模拟，测量多个激励和复极序列获得完整的狗。从长期植入心室心外膜的约90个电极和心房上的几个电极记录心外膜电位。在尸检中测量每个体表和心外膜电极的几何坐标。模拟的体表分布计算从心外膜的心脏体表传递系数的装置。这些传递系数是从所有电极的测量几何坐标推导出来的，假设心外膜和体表之间的体积导体是均匀的。结果包括多组等电位分布，每组包括测得的心外膜和体表分布以及模拟体表分布。在许多时刻，从心外膜测量的电位分布比从体表测量的分布复杂得多。尽管如此，模拟的体表分布始终具有较高的相关性与测量的身体分布。然而，模拟图通常具有较大的峰到峰幅度。结果表明，心脏和体表电活动的详细事件之间的定量关系，可以建立理论和现实的实验测量证实。
The objective of this study was to simulate body surface potential distributions, millisecond by millisecond, from potential distributions measured directly from the epicardium of the intact dog, and to examine the resulting simulation by comparing it with measured body surface potential distributions. Included in this objective was a simulation not only of those phases of cardiac activity involving depolarization, with which previous simulations have been concerned almost exclusively, but also of times of overlapping depolarization and repolarization, and times during repolarization alone. To achieve this simulation, measurements of multiple excitation and repolarization sequences were obtained from intact dogs. Epicardial potentials were recorded from about 90 electrodes chronically implanted on the ventricular epicardium, and several electrodes on the atria. Geometric coordinates of each body surface and epicardial electrode were measured in a postmortem examination. The simulated body surface distributions were computed from the epicardial ones by means of heart to body surface transfer coefficients. These transfer coefficients were derived from the measured geometric coordinates of all the electrodes with the assumption that the volume conductor was homogeneous between the epicardium and the body surface. Results included numerous sets of isopotential distributions, each set comprising the measured epicardial and body surface distributions, and the simulated body surface distribution. At many time instants, the distribution of potentials measured from the epicardium was considerably more complicated that the distribution measured from the body surface. Nonetheless, simulated body surface distributions consistently had a high correlation with the measured body distributions. However, the simulated maps usually had larger peak to peak magnitudes. The results demonstrate that quantitative relationships between the detailed events of cardiac and body surface electrical activity can be established theoretically and confirmed by realistic experimental measurements.