The public health imperative for a neonatal herpes simplex virus infection surveillance system
The public health imperative for a neonatal herpes simplex virus infection surveillance system
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DOI：
10.1097/01.olq.0000187203.27918.45
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发表时间：
2006-03-01
影响因子：
3.1
通讯作者：
Klausner, JD
中科院分区：
文献类型：
--
作者：
Donoval, BA;Passaro, DJ;Klausner, JD
在美国，大约五分之一的性活跃成年人有血清学证据表明生殖器疱疹是由2型单纯疱疹病毒引起的。新生儿单纯疱疹病毒感染是生殖器疱疹感染的严重后果。新生儿中的疱疹感染会导致严重的发病率和神经损害，一般情况下，未经治疗的病死率为60%。据估计，美国每年发生440至1320例新生儿疱疹感染(每10万名活产儿中有11至33例)。鉴于大量无症状感染和罕见的实验室诊断给生殖器疱疹监测带来的挑战，我们建议启动有效的国家疱疹感染控制计划，实施强制性的新生儿疱疹国家监测系统。这样的系统将有助于确保适当的治疗，有助于监测趋势和了解疾病的负担，确定风险决定因素，并评估预防工作。
About 1 in 5 sexually active adults in the United States has serologic evidence of genital herpes caused by herpes simplex virus type-2. Neonatal herpes simplex virus infection is a serious consequence of genital herpes infection. Herpes infection in neonates causes significant morbidity and neurologic damage and generally has a case-fatality ratio untreated of 60%. It is estimated that 440 to 1320 cases of neonatal herpes infections occur in the United States per year (11-33 cases occur per 100,000 live births). Given the challenges in surveillance for genital herpes due to the large number of asymptomatic infections and infrequent laboratory-based diagnosis, we recommend that to begin an effective national control program for herpes infections, a mandatory national surveillance system for neonatal herpes be implemented. Such a system would help assure appropriate therapy, help monitor trends and understand the burden of disease, identify risk determinants, and evaluate prevention efforts.