Atherosclerotic plaque metabolism in high cardiovascular risk subjects - A subclinical atherosclerosis imaging study with 18F-NaF PET-CT
Atherosclerotic plaque metabolism in high cardiovascular risk subjects - A subclinical atherosclerosis imaging study with 18F-NaF PET-CT
复制标题
DOI：
10.1016/j.atherosclerosis.2017.03.014
复制
发表时间：
2017-05-01
期刊：
影响因子：
5.3
通讯作者：
Ferreira, Maria Joao
中科院分区：
文献类型：
--
作者：
de Oliveira-Santos, Manuel;Castelo-Branco, Miguel;Ferreira, Maria Joao
背景和目的：正电子发射计算机断层扫描(PET-CT)中F-18-氟化钠(NaF)对动脉粥样硬化斑块的分子成像为区分活动性、不稳定性微钙化和已建立的隐匿性钙化提供了可能。本研究旨在研究心血管高危人群对F-18-NaF动脉粥样硬化斑块的摄取及其与心血管危险因素、冠状动脉钙化积分和胸腔脂肪体积的关系。方法：采用F-18-NaF-PET-CT对单中心高危高血压患者的冠状动脉、主动脉和颈总动脉进行前瞻性扫描。动脉粥样硬化斑块的F-18-NaF摄取量表示为每一病变的校正摄取量(CUL)：每个血管区域的最大标准摄取值减去平均血池活动。结果：平均年龄岁，男性56%，高加索人96%(n=25)。96%的受试者发现F-18-NaF摄取在主动脉(CUL0.9+/-0.3)，40%在颈动脉(中位数CUL0.0，IQR0.0~0.7)，%在冠状动脉(0.4IQR0.0~0.6)。具有5个风险因素的个体(60%)总体F-18-NaF摄取量增加(1.1+/-0.3比0.7+/-0.3，p<；0.01)，这与预测的致命心血管风险分数呈正相关(r=0.49，p=0.01)。冠状动脉摄取F-18-NaF与钙化积分无相关性(p=0.87)。胸腔脂肪与总CUL呈中度相关(r=0.41，p=0.04)。结论：在心血管高危人群中，F-18-NaF斑块摄取与心血管危险因素负荷及胸腔脂肪体积有关，而冠状动脉摄取与钙化积分无关。(C)2017爱思唯尔B.V.保留所有权利。
Background and aims: Atherosclerotic plaque molecular imaging with F-18-sodium fluoride (NaF) in positron emission tomography with computed tomography (PET-CT) provides potential discrimination between active unstable microcalcification and established dormant calcification. We aimed to study F-18-NaF atherosclerotic plaque uptake in high cardiovascular (CV) risk participants and its associations with CV risk factors, coronary calcium score and thoracic fat volume.Methods: High CV risk hypertensive individuals from a single centre were prospectively scanned with F-18-NaF-PET-CT in the coronary, aortic and carotideal arteries. Atherosclerotic plaque F-18-NaF uptake was expressed as Corrected Uptake per Lesion (CUL): maximum standard uptake value in each vascular territory subtracted by mean blood pool activity.Results: Mean age was 64 years, 56% male and 96% Caucasian (n = 25). Ninety six per cent of the subjects showed F-18-NaF uptake in the aorta (CUL 0.9 +/- 0.3), 40% in the carotid arteries (median CUL 0.0, IQR 0.0 -0.7) and 64% in the coronary arteries (0.4, IQR 0.0-0.6). Individuals with >= five risk factors (60%) had increased overall F-18-NaF uptake (1.1 +/- 0.3 vs. 0.7 +/- 0.3, p < 0.01), which was positively correlated with predicted fatal CV risk - SCORE (r = 0.49, p = 0.01). There was no correlation between F-18-NaF uptake in the coronary arteries and calcium score (p = 0.87). Thoracic fat was moderately correlated with overall CUL (r = 0.41, p = 0.04).Conclusions: In a high CV risk group, F-18-NaF atherosclerotic plaque uptake was related to the burden of CV risk factors and thoracic fat volume, but there was no association between coronary uptake and calcium score. (C) 2017 Elsevier B.V. All rights reserved.